PAN_AP divergent subfamily of APPLE domains
SMART ACC:	SM000473
Description:	Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.
InterPro ACC:	IPR003609
InterPro abstract:	Plasma kallikrein ( EC:3.4.21.34 ) and coagulation factor XI ( EC:3.4.21.27 ) are two related plasma serine proteases activated by factor XIIA and which share the same domain topology: an N-terminal region that contains four tandem repeats of about 90 amino … expand Plasma kallikrein ( EC:3.4.21.34 ) and coagulation factor XI ( EC:3.4.21.27 ) are two related plasma serine proteases activated by factor XIIA and which share the same domain topology: an N-terminal region that contains four tandem repeats of about 90 amino acids and a C-terminal catalytic domain. The 90 amino-acid repeated domain contains 6 conserved cysteines. It has been shown [ PUBMED:1998666 PUBMED:1998667 ] that three disulfide bonds link the first and sixth, second and fifth, and third and fourth cysteines. The domain can be drawn in the shape of an apple and has been accordingly called the 'apple domain'. The apple domains of plasma prekallikrein are known to mediate its binding to high molecular weight kininogen [ PUBMED:8662705 ], the apple domains of factor XI bind to factor XIIa, platelets, kininogen, factor IX and heparin [ PUBMED:9632702 ]. The apple domains display some sequence similarity with the N domain of plasminogen/hepatocyte growth factor (HGF) and to some nematode and protozoan proteins [ PUBMED:10561497 ]. They all belong to the same domain superfamily that have been called the PAN module [ PUBMED:11376658 ]. The N domain of hepatocyte growth factor binds to the c-Met receptor and to the heparin molecule. The structure of the PAN module of HGF has been solved. It contains a characteristic hairpin-loop structure stabilised by two disulfide bridges, Cys-1 and 6 are not conserved in HGF PAN modules [ PUBMED:9493272 ]. Apart from the cysteines, there are a number of other conserved positions in the apple domain. This entry represents the PAN domain of the plasma kalllikrein/coagulation factor XI subgroup proteins. collapse
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 16 227 PAN_AP domains in 10 380 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing PAN_AP domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing PAN_AP domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the PAN_AP domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a PAN_AP domain which could be assigned to a KEGG orthologous group, and not all proteins containing PAN_AP domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

InterPro	IPR003609