The domain within your query sequence starts at position 196 and ends at position 290; the E-value for the BACK domain shown below is 5e-25.


The domain was found using the schnipsel database


BTB And C-terminal Kelch
SMART accession number:SM00875
Description: The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.
Interpro abstract (IPR011705):

This domain is found associated with ( IPR000210 ) and ( IPR006652 ). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [ (PUBMED:16207353) ]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB fold is highly conserved.

BTB-Kelch proteins have Kelch repeats that form a beta-propeller that can interact with actin filaments [ (PUBMED:15544948) ]. BTB and C-terminal Kelch (BACK) together constitute a novel conserved domain, which is thought to have a possible role in substrate orientation in Cullin3-based E3 ligase complexes.

Four domains, namely the BTB domain, a kelch domain, a BACK domain, and an intervening region (IVR) make up the aryl hydrocarbon receptor (AHR); a ligand-activated transcription factor [ (PUBMED:16582008) ]. This entry represents the domain associated with BTB and Kelch.

Family alignment:
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There are 27812 BACK domains in 27689 proteins in SMART's nrdb database.

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