PDB code | Main view | Title | 1e7u |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e7v |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8w |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8x |  | STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING |
1e8y |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e8z |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1e90 |  | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine |
1he8 |  | Ras G12V - PI 3-kinase gamma complex |
2a4z |  | Crystal Structure of human PI3Kgamma complexed with AS604850 |
2a5u |  | Crystal Structure of human PI3Kgamma complexed with AS605240 |
2chw |  | A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39 |
2chx |  | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-90 |
2chz |  | A pharmacological map of the PI3-K family defines a role for p110alpha in signaling: The structure of complex of phosphoinositide 3-kinase gamma with inhibitor PIK-93. |
2rd0 |  | Structure of a human p110alpha/p85alpha complex |
2v4l |  | complex of human phosphoinositide 3-kinase catalytic subunit gamma ( p110 gamma) with PIK-284 |
2wxf |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with PIK-39. |
2wxg |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW13. |
2wxh |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW14. |
2wxi |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with SW30. |
2wxj |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK654. |
2wxk |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with INK666. |
2wxl |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with ZSTK474. |
2wxm |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL06. |
2wxn |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with DL07. |
2wxo |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS5. |
2wxp |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with GDC-0941. |
2wxq |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with AS15. |
2wxr |  | The crystal structure of the murine class IA PI 3-kinase p110delta. |
2x38 |  | The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114. |
2x6f |  | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE |
2x6h |  | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 |
2x6i |  | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90 |
2x6j |  | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93 |
2x6k |  | THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103 |
2y3a |  | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 |
3apc |  | Crystal structure of human PI3K-gamma in complex with CH5132799 |
3apd |  | Crystal structure of human PI3K-gamma in complex with CH5108134 |
3apf |  | Crystal structure of human PI3K-gamma in complex with CH5039699 |
3csf |  | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2 |
3cst |  | Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2 |
3dbs |  | Structure of PI3K gamma in complex with GDC0941 |
3dpd |  | Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-Dihydro-2H-benzo[1,4]oxazines |
3ene |  | Complex of PI3K gamma with an inhibitor |
3hhm |  | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin |
3hiz |  | Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha |
3ibe |  | Crystal Structure of a Pyrazolopyrimidine Inhibitor Bound to PI3 Kinase Gamma |
3ihy |  | Human PIK3C3 crystal structure |
3jbz |  | 3JBZ |
3l08 |  | Structure of Pi3K gamma with a potent inhibitor: GSK2126458 |
3l13 |  | Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors |
3l16 |  | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer |
3l17 |  | Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer |
3l54 |  | Structure of Pi3K gamma with inhibitor |
3lj3 |  | PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor |
3ls8 |  | Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol |
3mjw |  | PI3 Kinase gamma with a benzofuranone inhibitor |
3ml8 |  | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design |
3ml9 |  | Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design |
3nzs |  | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase |
3nzu |  | Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase |
3oaw |  | 4-Methylpteridineones as Orally Active and Selective PI3K/mTOR Dual Inhibitors |
3p2b |  | Crystal Structure of PI3K gamma with 3-(2-morpholino-6-(pyridin-3-ylamino)pyrimidin-4-yl)phenol |
3pre |  | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3prz |  | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3ps6 |  | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. |
3qaq |  | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 1 |
3qar |  | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32 |
3qjz |  | Crystal structure of PI3K-gamma in complex with benzothiazole 1 |
3qk0 |  | Crystal structure of PI3K-gamma in complex with benzothiazole 82 |
3r7q |  | Structure-based design of thienobenzoxepin inhibitors of PI3- kinase |
3r7r |  | Structure-based design of thienobenzoxepin inhibitors of PI3-Kinase |
3s2a |  | Crystal structure of PI3K-gamma in complex with a quinoline inhibitor |
3sd5 |  | Crystal Structure of PI3K gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine |
3t8m |  | Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform |
3tjp |  | Crystal Structure of PI3K gamma with N6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine |
3tl5 |  | Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer |
3zim |  | Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha |
3zvv |  | Fragment Bound to PI3KInase gamma |
3zw3 |  | Fragment based discovery of a novel and selective PI3 Kinase inhibitor |
4a55 |  | Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 |
4ajw |  | Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers"" |
4anu |  | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anv |  | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anw |  | Complexes of PI3Kgamma with isoform selective inhibitors. |
4anx |  | Complexes of PI3Kgamma with isoform selective inhibitors. |
4aof |  | Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of Th17 cell differentiation by PI3Kgamma |
4bfr |  | Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue ( PTEN)-Deficient Cancers |
4d0l |  | 4D0L |
4d0m |  | 4D0M |
4dk5 |  | Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor |
4ezj |  | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4ezk |  | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4ezl |  | Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf |
4f1s |  | Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor |
4fa6 |  | Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR |
4fad |  | Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR |
4fhj |  | Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 |
4fhk |  | Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e |
4fjy |  | Crystal structure of PI3K-gamma in complex with quinoline-indoline inhibitor 24f |
4fjz |  | Crystal structure of PI3K-gamma in complex with pyrrolo-pyridine inhibitor 63 |
4flh |  | Crystal structure of human PI3K-gamma in complex with AMG511 |
4ful |  | PI3 Kinase Gamma bound to a pyrmidine inhibitor |
4g11 |  | X-ray structure of PI3K-gamma bound to a 4-(morpholin-4-yl)- (6-oxo-1,6-dihydropyrimidin-2-yl)amide inhibitor |
4gb9 |  | Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta |
4hle |  | Compound 21 (1-alkyl-substituted 1,2,4-triazoles) |
4hvb |  | Catalytic unit of PI3Kg in complex with PI3K/mTOR dual inhibitor PF-04979064 |
4j6i |  | Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform |
4jps |  | Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors |
4jsn |  | structure of mTORdeltaN-mLST8 complex |
4jsp |  | structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex |
4jsv |  | mTOR kinase structure, mechanism and regulation. |
4jsx |  | structure of mTORDeltaN-mLST8-Torin2 complex |
4jt5 |  | mTORdeltaN-mLST8-pp242 complex |
4jt6 |  | structure of mTORDeltaN-mLST8-PI-103 complex |
4kz0 |  | Structure of PI3K gamma with Imidazopyridine inhibitors |
4kzc |  | Structure of PI3K gamma with Imidazopyridine inhibitors |
4l1b |  | Crystal Structure of p110alpha complexed with niSH2 of p85alpha |
4l23 |  | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 |
4l2y |  | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d |
4ovu |  | 4OVU |
4ovv |  | 4OVV |
4oys |  | 4OYS |
4ph4 |  | 4PH4 |
4ps3 |  | Structure of PI3K gamma in complex with 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea |
4ps7 |  | Structure of PI3K gamma in complex with N-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide |
4ps8 |  | Structure of PI3K gamma in complex with N-[6-(5,6-dimethoxypyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide |
4tuu |  | 4TUU |
4tv3 |  | 4TV3 |
4urk |  | 4URK |
4uwf |  | 4UWF |
4uwg |  | 4UWG |
4uwh |  | 4UWH |
4uwk |  | 4UWK |
4uwl |  | 4UWL |
4v0i |  | 4V0I |
4wae |  | 4WAE |
4waf |  | 4WAF |
4wag |  | 4WAG |
4wwn |  | 4WWN |
4wwo |  | 4WWO |
4wwp |  | 4WWP |
4xe0 |  | 4XE0 |
4xx5 |  | 4XX5 |
4xz4 |  | 4XZ4 |
4ykn |  | 4YKN |
4zop |  | 4ZOP |
5ae8 |  | 5AE8 |
5ae9 |  | 5AE9 |
5anl |  | 5ANL |
5c46 |  | 5C46 |
5c4g |  | 5C4G |
5dfz |  | 5DFZ |
5dxh |  | 5DXH |
5dxt |  | 5DXT |
5dxu |  | 5DXU |
5eds |  | 5EDS |
5enn |  | 5ENN |
5euq |  | 5EUQ |
5fi4 |  | 5FI4 |
5flc |  | 5FLC |
5fvm |  | 5FVM |
5g2n |  | 5G2N |
5g55 |  | 5G55 |
5is5 |  | 5IS5 |
5itd |  | 5ITD |
5kc2 |  | 5KC2 |
5l72 |  | 5L72 |