The domain within your query sequence starts at position 122 and ends at position 218; the E-value for the RPOLA_N domain shown below is 5e-43.


The domain was found using the schnipsel database


RNA polymerase I subunit A N-terminus
SMART accession number:SM00663
Description: -
Interpro abstract (IPR006592):

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA [ (PUBMED:10684922) ]. Pol I transcription is localised to discrete sites called nucleoli; these can be likened to ribosome factories, in which rRNA is synthesised by pol I in the fibrillar centres and then processed and assembled into ribosomes in the surrounding granular regions [ (PUBMED:8689574) ]. Prokaryotes, in contrast, posses a single RNA polymerase, with transcription being controlled by the particular signam factor interacting with the catalytic core.

This entry describes an N-terminal conserved region which can be found in the largest subunits of prokaryoptic and eukaryotic RNA polymerases.

GO process:transcription, DNA-templated (GO:0006351)
GO function:DNA binding (GO:0003677), DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
Family alignment:
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There are 32556 RPOLA_N domains in 32547 proteins in SMART's nrdb database.

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