The domain within your query sequence starts at position 2 and ends at position 78; the E-value for the UreE_C domain shown below is 9e-50.

LVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSA
RCAQFPRAQDKVHYYIK

The domain was found using the schnipsel database

UreE_C

UreE urease accessory protein, C-terminal domain

• SMART accession number: SM00987
• Description: UreE is a urease accessory protein. Urease hydrolyses urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.

There are 48577 UreE_C domains in 48571 proteins in SMART's nrdb database.

Cellular role (predicted cellular role)

Cellular role: metabolism

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Song HK, Mulrooney SB, Huber R, Hausinger RP
• Crystal structure of Klebsiella aerogenes UreE, a nickel-bindingmetallochaperone for urease activation.
• J Biol Chem. 2001; 276: 49359-64

UreE is proposed to be a metallochaperone that delivers nickel ions tourease during activation of this bacterial virulence factor. Wild-typeKlebsiella aerogenes UreE binds approximately six nickel ions perhomodimer, whereas H144*UreE (a functional C-terminal truncated variant)was previously reported to bind two. We determined the structure ofH144*UreE by multi-wavelength anomalous diffraction and refined it to 1.5A resolution. The present structure reveals an Hsp40-like peptide-bindingdomain, an Atx1-like metal-binding domain, and a flexible C terminus.Three metal-binding sites per dimer, defined by structural analysis ofCu-H144*UreE, are on the opposite face of the Atx1-like domain thanobserved in the copper metallochaperone. One metal bridges the twosubunits via the pair of His-96 residues, whereas the other two sitesinvolve metal coordination by His-110 and His-112 within each subunit. Incontrast to the copper metallochaperone mechanism involving thiol ligandexchanges between structurally similar chaperones and target proteins, wepropose that the Hsp40-like module interacts with urease apoprotein and/orother urease accessory proteins, while the Atx1-like domain delivershistidyl-bound nickel to the urease active site.

Structure (3D structures containing this domain)

3D Structures of UreE_C domains in PDB

PDB code	Title
1akz	HUMAN URACIL-DNA GLYCOSYLASE
1emh	CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA
1emj	URACIL-DNA GLYCOSYLASE BOUND TO DNA CONTAINING A 4'-THIO-2'DEOXYURIDINE ANALOG PRODUCT
1eug	CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
1eui	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
1flz	URACIL DNA GLYCOSYLASE WITH UAAP
1l9g	CRYSTAL STRUCTURE OF URACIL-DNA GLYCOSYLASE FROM T. MARITIMA
1lau	URACIL-DNA GLYCOSYLASE
1lqg	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
1lqj	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE
1lqm	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
1mtl	Non-productive MUG-DNA complex
1mug	G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI
1mwi	Crystal structure of a MUG-DNA product complex
1mwj	Crystal Structure of a MUG-DNA pseudo substrate complex
1okb	crystal structure of Uracil-DNA glycosylase from Atlantic cod (Gadus morhua)
1q3f	Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA
1ssp	WILD-TYPE URACIL-DNA GLYCOSYLASE BOUND TO URACIL-CONTAINING DNA
1udg	THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
1udh	THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
1udi	NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX
1ugh	CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE IN COMPLEX WITH A PROTEIN INHIBITOR: PROTEIN MIMICRY OF DNA
1ui0	Crystal Structure Of Uracil-DNA Glycosylase From Thermus Thermophilus HB8
1ui1	Crystal Structure Of Uracil-DNA Glycosylase From Thermus Thermophilus HB8
1uug	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH WILD-TYPE UDG AND WILD-TYPE UGI
1vk2	Crystal structure of Uracil-DNA glycosylase (TM0511) from Thermotoga maritima at 1.90 A resolution
1wyw	Crystal Structure of SUMO1-conjugated thymine DNA glycosylase
1yuo	Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG)from atlantic cod (Gadus morhua)
2boo	The crystal structure of Uracil-DNA N-Glycosylase (UNG) from Deinococcus radiodurans.
2c53	A comparative study of uracil DNA glycosylases from human and herpes simplex virus type 1
2c56	A comparative study of uracil DNA glycosylases from human and herpes simplex virus type 1
2d07	Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase
2d3y	Crystal structure of uracil-DNA glycosylase from Thermus Thermophilus HB8
2ddg	Crystal structure of uracil-DNA glycosylase in complex with AP:G containing DNA
2dem	Crystal structure of Uracil-DNA glycosylase in complex with AP:A containing DNA
2dp6	Crystal structure of uracil-DNA glycosylase in complex with AP:C containing DNA
2eug	CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
2hxm	Complex of UNG2 and a small Molecule synthetic Inhibitor
2j8x	Epstein-Barr virus uracil-DNA glycosylase in complex with Ugi from PBS-2
2jhq	Crystal structure of Uracil DNA-glycosylase from Vibrio cholerae
2l3f	Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76
2oxm	Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping
2oyt	Crystal Structure of UNG2/DNA(TM)
2rba	Structure of Human Thymine DNA Glycosylase Bound to Abasic and Undamaged DNA
2ssp	LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA
2uug	ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI
2zhx	Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor
3a7n	Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis
3cxm	Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil
3eug	CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
3fcf	Complex of UNG2 and a fragment-based designed inhibitor
3fci	Complex of UNG2 and a fragment-based designed inhibitor
3fck	Complex of UNG2 and a fragment-based design inhibitor
3fcl	Complex of UNG2 and a fragment-based designed inhibitor
3ikb	The structure of a conserved protein from Streptococcus mutans UA159.
3tkb	crystal structure of human uracil-DNA glycosylase D183G/K302R mutant
3tr7	Structure of a uracil-DNA glycosylase (ung) from Coxiella burnetii
3uf7	Co-crystal structure of Escherichia coli uracil-DNA glycosylase and a C-terminal fragement of the single-stranded DNA-binding protein
3ufj	Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-fluoro-2'-deoxyuridine
3ufm	Co-crystal structure of Deinococcus radiodurans uracil-DNA glycosylase and the C-terminus of the single-stranded DNA-binding protein
3uo7	Crystal structure of Human Thymine DNA Glycosylase Bound to Substrate 5-carboxylcytosine
3uob	Crystal structure of Human Thymine DNA Glycosylase Bound to Substrate Analog 2'-deoxy-2'-beta-fluoro-cytidine
3wdf	Staphylococcus aureus UDG
3wdg	Staphylococcus aureus UDG / UGI complex
3zoq	Structure of BsUDG-p56 complex
3zor	Structure of BsUDG
4eug	Crystallographic and Enzymatic Studies of an Active Site Variant H187Q of Escherichia Coli Uracil DNA Glycosylase: Crystal Structures of Mutant H187Q and its Uracil Complex
4fnc	Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
4jgc	Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)
4l5n	Crystallographic Structure of HHV-1 Uracil-DNA Glycosylase complexed with the Bacillus phage PZA inhibitor protein p56
4lyl	4LYL
4skn	A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA
4uqm	4UQM
4wpk	4WPK
4wpl	4WPL
4wru	4WRU
4wrv	4WRV
4wrw	4WRW
4wrx	4WRX
4wry	4WRY
4wrz	4WRZ
4ws0	4WS0
4ws1	4WS1
4ws2	4WS2
4ws3	4WS3
4ws4	4WS4
4ws5	4WS5
4ws6	4WS6
4ws7	4WS7
4ws8	4WS8
4xeg	4XEG
4z3a	4Z3A
4z47	4Z47
4z7b	4Z7B
4z7z	4Z7Z
4zbx	4ZBX
4zby	4ZBY
4zbz	4ZBZ
5ayr	5AYR
5ays	5AYS
5cys	5CYS
5eug	CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
5ff8	5FF8
5h93	5H93
5h98	5H98
5h99	5H99
5h9i	5H9I
5hf7	5HF7
5jk7	5JK7
5jxy	5JXY
5t2w	5T2W

Links (links to other resources describing this domain)

• PFAM: UreE_C