CBM49 Carbohydrate binding domain CBM49
SMART ACC:	SM001063
Description:	This domain is found at the C terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose (PUBMED:17322304) .
InterPro ACC:	IPR019028
InterPro abstract:	A carbohydrate-binding module (CBM) is defined as a contiguous amino acid sequence within a carbohydrate-active enzyme with a discreet fold having carbohydrate-binding activity. A few exceptions are CBMs in cellulosomal scaffolding proteins and rare instances of independent putative CBMs. The requirement of CBMs existing as modules within larger enzymes sets this class of carbohydrate-binding … expand A carbohydrate-binding module (CBM) is defined as a contiguous amino acid sequence within a carbohydrate-active enzyme with a discreet fold having carbohydrate-binding activity. A few exceptions are CBMs in cellulosomal scaffolding proteins and rare instances of independent putative CBMs. The requirement of CBMs existing as modules within larger enzymes sets this class of carbohydrate-binding protein apart from other non-catalytic sugar binding proteins such as lectins and sugar transport proteins. CBMs were previously classified as cellulose-binding domains (CBDs) based on the initial discovery of several modules that bound cellulose [ PUBMED:3338453 PUBMED:3134347 ]. However, additional modules in carbohydrate-active enzymes are continually being found that bind carbohydrates other than cellulose yet otherwise meet the CBM criteria, hence the need to reclassify these polypeptides using more inclusive terminology. Previous classification of cellulose-binding domains were based on amino acid similarity. Groupings of CBDs were called "Types" and numbered with roman numerals (e.g. Type I or Type II CBDs). In keeping with the glycoside hydrolase classification, these groupings are now called families and numbered with Arabic numerals. Families 1 to 13 are the same as Types I to XIII. For a detailed review on the structure and binding modes of CBMs see [ PUBMED:15214846 ]. This domain is found at the C-terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose [ PUBMED:17322304 ]. collapse
GO function:	carbohydrate binding (GO:0030246)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 624 CBM49 domains in 588 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing CBM49 domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CBM49 domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:	Metabolic
Binding / catalysis:	Cellulose

Relevant references for this domain

Primary literature for the CBM49 domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CBM49 domain which could be assigned to a KEGG orthologous group, and not all proteins containing CBM49 domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

Links to other resources describing this domain

InterPro	IPR019028
Pfam	CBM49