 CRM1_CCRM1 C terminal | |
|---|---|
| SMART ACC: | SM001102 |
| Description: | CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat (PUBMED:15574331). |
| InterPro ACC: | IPR014877 |
| InterPro abstract: | CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This entry represents the C-terminal domain of CRM1. It forms an α helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little … expand |
| GO function: | nuclear export signal receptor activity (GO:0005049) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 1 759 CRM1_C domains in 1 757 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing CRM1_C domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing CRM1_C domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: |
|---|
Relevant references for this domain
Primary literature for the CRM1_C domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a CRM1_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing CRM1_C domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.