Copper-fist

Copper-fist

SMART ACC:SM001090
Description:Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist. It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.
Family alignment:View the Family alignment or the Alignment consensus sequence
There are 1 201 Copper-fist domains in 1 201 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing Copper-fist domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing Copper-fist domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Predicted cellular role

Cellular role:Transcription
Binding / catalysis:DNA binding

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a Copper-fist domain which could be assigned to a KEGG orthologous group, and not all proteins containing Copper-fist domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

Some of these pathways are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

KEGG orthologous groups

Some of these KOs are included in the interactive Pathways Explorer overview maps. Select an overview map and click the button below to highlight them in iPath.

3D structures in PDB containing this domain

Links to other resources describing this domain

PfamCopper-fist