 DDHD | |
|---|---|
| SMART ACC: | SM001127 |
| Description: | The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3) ((PUBMED:10022914)). This suggests that this region is involved in functionally important interactions in other members of this family. |
| InterPro ACC: | IPR004177 |
| InterPro abstract: | The Nir/rdgB (N-terminal domain-interacting receptor/Drosophila retinal degeneration B proteins) family has been identified in a variety of eukaryotic organisms, ranging from worms to mammals. Members of this family are implicated in regulation of lipid trafficking, metabolism, and signaling. The Nir/rdgB proteins contain a 180 amino-acids-long conserved region in the central part of the protein. … expand |
| GO function: | metal ion binding (GO:0046872) |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 5 144 DDHD domains in 5 140 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing DDHD domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing DDHD domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Metabolic |
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Relevant references for this domain
Primary literature for the DDHD domain is listed below. Automatically-derived, secondary literature is also available.
KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a DDHD domain which could be assigned to a KEGG orthologous group, and not all proteins containing DDHD domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.