DUF1785

DUF1785
SMART accession number:SM01163
Description: This region is found in argonaute [(PUBMED:16216572)] proteins and often co-occurs with BAG (SM00264) and Piwi (SM00950).
Interpro abstract (IPR014811):

ArgoL1 is a region found in argonaute [ (PUBMED:16216572) ] proteins. It normally co-occurs with BAG domain ( IPR003103 ) and Piwi domain ( IPR003165 ). It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold [ (PUBMED:16061186) ].

Family alignment:
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There are 6460 DUF1785 domains in 6418 proteins in SMART's nrdb database.

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