Activation of NF-kappaB as a consequence of signalling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT (Evolutionarily conserved signaling intermediate in Toll pathway) plays an important role in signalling to NF-kappaB, functioning as an adapter protein of the Toll-like and IL-1 receptor signalling pathway and an intermediary in the signalling pathways … expand

Activation of NF-kappaB as a consequence of signalling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT (Evolutionarily conserved signaling intermediate in Toll pathway) plays an important role in signalling to NF-kappaB, functioning as an adapter protein of the Toll-like and IL-1 receptor signalling pathway and an intermediary in the signalling pathways between TRAF-6 and MEKK-1 [ PUBMED:10465784 ]. It is part of the MCIA (mitochondrial complex I intermediate assembly) complex, involved in the assembly of mitochondrial complex I [ PUBMED:32320651 ].

This entry represents the C-terminal domain of ECSIT, which is missing in isoform 2. This domain may be distantly homologous to the pleckstrin homology domain.