The domain within your query sequence starts at position 1364 and ends at position 1413; the E-value for the EGF_like domain shown below is 8.13e-1.
LAGSPPAHLIERCDCPPGYSGLSCETCAPGFYRLRSEPGGRTPGPTLGTC
EGF_likeEGF domain, unclasssified subfamily |
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SMART accession number: | SM00001 |
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Description: | - |
Family alignment: |
There are 116150 EGF_like domains in 57116 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing EGF_like domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with EGF_like domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing EGF_like domain in the selected taxonomic class.
- Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 19.93 map04512 ECM-receptor interaction 18.82 map04510 Focal adhesion 7.75 map05222 Small cell lung cancer 7.20 map04810 Regulation of actin cytoskeleton 5.17 map04330 Notch signaling pathway 4.98 map04514 Cell adhesion molecules (CAMs) 4.43 map04360 Axon guidance 2.21 map05060 Prion disease 2.03 map04670 Leukocyte transendothelial migration 1.66 map04320 Dorso-ventral axis formation 1.48 map04060 Cytokine-cytokine receptor interaction 1.48 map04012 ErbB signaling pathway 1.29 map05212 Pancreatic cancer 1.29 map04610 Complement and coagulation cascades 1.29 map04010 MAPK signaling pathway 1.29 map05215 Prostate cancer 1.29 map04340 Hedgehog signaling pathway 1.11 map05219 Bladder cancer 1.11 map05213 Endometrial cancer 1.11 map05010 Alzheimer's disease 1.11 map05214 Glioma 1.11 map05223 Non-small cell lung cancer 1.11 map04540 Gap junction 1.11 map05218 Melanoma 0.74 map00590 Arachidonic acid metabolism 0.74 map04640 Hematopoietic cell lineage 0.55 map00350 Tyrosine metabolism 0.55 map04310 Wnt signaling pathway 0.55 map00740 Riboflavin metabolism 0.55 map04916 Melanogenesis 0.55 map00310 Lysine degradation 0.55 map00950 Alkaloid biosynthesis I 0.55 map04650 Natural killer cell mediated cytotoxicity 0.37 map04350 TGF-beta signaling pathway 0.37 map04620 Toll-like receptor signaling pathway 0.18 map04520 Adherens junction 0.18 map05120 Epithelial cell signaling in Helicobacter pylori infection 0.18 map00910 Nitrogen metabolism 0.18 map04662 B cell receptor signaling pathway 0.18 map05220 Chronic myeloid leukemia 0.18 map04920 Adipocytokine signaling pathway 0.18 map00632 Benzoate degradation via CoA ligation 0.18 map00562 Inositol phosphate metabolism 0.18 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 0.18 map04210 Apoptosis 0.18 map04910 Insulin signaling pathway 0.18 map04660 T cell receptor signaling pathway 0.18 map05221 Acute myeloid leukemia 0.18 map04930 Type II diabetes mellitus This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EGF_like domain which could be assigned to a KEGG orthologous group, and not all proteins containing EGF_like domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of EGF_like domains in PDB
PDB code Main view Title 1aut HUMAN ACTIVATED PROTEIN C 1c5m STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 1dan COMPLEX OF ACTIVE SITE INHIBITED HUMAN BLOOD COAGULATION FACTOR VIIA WITH HUMAN RECOMBINANT SOLUBLE TISSUE FACTOR 1dva Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor VIIA 1dx5 Crystal structure of the thrombin-thrombomodulin complex 1ezq CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 1f0r CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 1f0s Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707 1fak HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT 1fax COAGULATION FACTOR XA INHIBITOR COMPLEX 1g2l FACTOR XA INHIBITOR COMPLEX 1g2m FACTOR XA INHIBITOR COMPLEX 1hj7 NMR study of a pair of LDL receptor Ca2+ binding epidermal growth factor-like domains, 20 structures 1hz8 SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR 1i0u SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR 1ioe Human coagulation factor Xa in complex with M55532 1iqe Human coagulation factor Xa in complex with M55590 1iqf Human coagulation factor Xa in complex with M55165 1iqg Human coagulation factor Xa in complex with M55159 1iqh Human coagulation factor Xa in complex with M55143 1iqi Human coagulation factor Xa in complex with M55125 1iqj Human coagulation factor Xa in complex with M55124 1iqk Human coagulation factor Xa in complex with M55113 1iql Human coagulation factor Xa in complex with M54476 1iqm Human coagulation factor Xa in complex with M54471 1iqn Human coagulation factor Xa in complex with M55192 1ksn Crystal Structure of Human Coagulation Factor XA Complexed with FXV673 1lpg CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79. 1lpk CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125. 1lpz CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41. 1lqd CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45. 1n7d Extracellular domain of the LDL receptor 1nfu CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR132747 1nfw CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR209685 1nfx CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208944 1nfy CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR200095 1o5d Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA) 1p0s Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R 1pfx PORCINE FACTOR IXA 1w0y tf7a_3771 complex 1w2k tf7a_4380 complex 1wqv Human Factor Viia-Tissue Factor Complexed with propylsulfonamide-D-Thr-Met-p-aminobenzamidine 1wss Human Factor Viia-Tissue Factor in Complex with peprid mimetic inhibitor that has two charge groups in P2 and P4 1wtg Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-biphenylalanine-Gln-p-aminobenzamidine 1wu1 Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine 1wun Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-Trp-Gln-p-aminobenzamidine 1wv7 Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-5-propoxy-Trp-Gln-p-aminobenzamidine 1x7a Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 1xka FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID 1xkb FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID 1z6j Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor 2a2q Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor in the Presence of Ca2+, Mg2+, Na+, and Zn2+ 2aei Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid 2aer Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex. 2b7d Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model 2b8o Crystal Structure of Glu-Gly-Arg-Chloromethyl Ketone-Factor VIIa/Soluble Tissue Factor Complex 2bo2 EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium. 2boh Crystal structure of factor Xa in complex with compound ""1"" 2bou EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium. 2box EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium. 2c4f crystal structure of factor VII.stf complexed with pd0297121 2cji Crystal structure of a Human Factor Xa inhibitor complex 2e26 Crystal structure of two repeat fragment of reelin 2ec9 Crystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-3607 2f9b Discovery of Novel Heterocyclic Factor VIIa Inhibitors 2fir Crystal structure of DFPR-VIIa/sTF 2flb Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor 2flr Novel 5-Azaindole Factor VIIa Inhibitors 2gy5 Tie2 Ligand-Binding Domain Crystal Structure 2gy7 Angiopoietin-2/Tie2 Complex Crystal Structure 2h9e Crystal Structure of FXa/selectide/NAPC2 ternary complex 2j2u CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2j34 CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2j38 CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2j4i CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2j94 CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2j95 CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX 2kl7 Solution NMR Structure of the EGF-like 1 Domain of Human Fibulin-4. Northeast Structural Genomics Target HR6275 2uwl Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa 2uwo Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa 2uwp Factor Xa inhibitor complex 2vh0 Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs 2vh6 Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs 2vj2 Human Jagged-1, domains DSL and EGFs1-3 2w2m WT PCSK9-DELTAC BOUND TO WT EGF-A OF LDLR 2w2n WT PCSK9-deltaC bound to EGF-A H306Y mutant of LDLR 2w2o PCSK9-deltaC D374Y mutant bound to WT EGF-A of LDLR 2w2p PCSK9-deltaC D374A mutant bound to WT EGF-A of LDLR 2w2q PCSK9-deltaC D374H mutant bound to WT EGF-A of LDLR 2wyg Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs 2wyj Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs 2x10 Crystal structure of the complete EphA2 ectodomain 2x11 Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain 2y7x The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs 2y7z Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs 2y80 Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs 2y81 Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs 2y82 Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs 2zp0 Human factor viia-tissue factor complexed with benzylsulfonamide-D-ile-gln-P-aminobenzamidine 2zwl Human factor viia-tissue factor complexed with highly selective peptide inhibitor 2zzu Human Factor VIIA-Tissue Factor Complexed with ethylsulfonamide-D-5-(3-carboxybenzyloxy)-Trp-Gln-p-aminobenzamidine 3a7q Structural basis for specific recognition of reelin by its receptors 3bps PCSK9:EGF-A complex 3ela Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor 3ens Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate 3fl7 Crystal structure of the human ephrin A2 ectodomain 3gcw PCSK9:EGFA(H306Y) 3gcx PCSK9:EGFA (pH 7.4) 3hpt Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine 3k9x X-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE 3m0c The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor 3mbw Crystal structure of the human ephrin A2 LBD and CRD domains in complex with ephrin A1 3mx0 Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 3ooi Crystal Structure of Human Histone-Lysine N-methyltransferase NSD1 SET domain in Complex with S-adenosyl-L-methionine 3p5b The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation 3p5c The structure of the LDLR/PCSK9 complex reveals the receptor in an extended conformation 3s8v Crystal structure of LRP6-Dkk1 complex 3s8z Crystal structure of LRP6-E3E4 3sw2 X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide 3th2 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 3th3 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 3th4 Mg2+ Is Required for Optimal Folding of the Gamma-Carboxyglutamic Acid (Gla) Domains of Vitamin K-Dependent Clotting Factors At Physiological Ca2+ 3v65 Crystal structure of agrin and LRP4 complex 3zyj NetrinG1 in complex with NGL1 4a7i Factor Xa in complex with a potent 2-amino-ethane sulfonamide inhibitor 4aqs Laminin beta1 LN-LE1-4 structure 4bti factor Xa in complex with the dual thrombin-FXa inhibitor 58. 4btt factor Xa in complex with the dual thrombin-FXa inhibitor 31. 4btu Factor Xa in complex with the dual thrombin-FXa inhibitor 57. 4bxs Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis 4bxw Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis 4cbz Notch ligand, Jagged-1, contains an N-terminal C2 domain 4cc0 Notch ligand, Jagged-1, contains an N-terminal C2 domain 4cc1 Notch ligand, Jagged-1, contains an N-terminal C2 domain 4d90 Crystal Structure of Del-1 EGF domains 4ibl Rubidium Sites in Blood Coagulation Factor VIIa 4k0v Structural basis for angiopoietin-1 mediated signaling initiation 4um8 4UM8 4um9 4UM9 4xbm 4XBM 4y6d 4Y6D 4y71 4Y71 4y76 4Y76 4y79 4Y79 4y7a 4Y7A 4y7b 4Y7B 4ylq 4YLQ 4yz8 4YZ8 4zh8 4ZH8 4zha 4ZHA 4zma 4ZMA 5bo1 5BO1 5fm9 5FM9 5fma 5FMA 5jb8 5JB8 5jb9 5JB9 5jba 5JBA 5jbb 5JBB 5jbc 5JBC 5lsu 5LSU