The domain within your query sequence starts at position 26 and ends at position 76; the E-value for the FHA domain shown below is 1.03e-11.



Forkhead associated domain
SMART accession number:SM00240
Description: Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.
Interpro abstract (IPR000253):

The forkhead-associated (FHA) domain [ (PUBMED:7482699) ] is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contain small helical insertions between the loops connecting the strands [ (PUBMED:11911881) ].

To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.

GO function:protein binding (GO:0005515)
Family alignment:
View or

There are 73373 FHA domains in 68942 proteins in SMART's nrdb database.

Click on the following links for more information.