Taxonomic distribution of proteins containing FIST domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing FIST domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

FIST: a sensory domain for diverse signal transduction pathways inprokaryotes and ubiquitin signaling in eukaryotes.

Borziak K, Zhulin IB
Bioinformatics. 2007; 23: 2518-21

MOTIVATION: Sensory domains that are conserved among Bacteria, Archaea andEucarya are important detectors of common signals detected by livingcells. Due to their high sequence divergence, sensory domains aredifficult to identify. We systematically look for novel sensory domainsusing sensitive profile-based searches initiated with regions of signaltransduction proteins where no known domains can be identified by currentdomain models. RESULTS: Using profile searches followed by multiplesequence alignment, structure prediction and domain architecture analysis,we have identified a novel sensory domain termed FIST, which is present insignal transduction proteins from Bacteria, Archaea and Eucarya.Chromosomal proximity of FIST-encoding genes to those coding for proteinsinvolved in amino acid metabolism and transport suggest that FIST domainsbind small ligands, such as amino acids.