 GCK | |
|---|---|
| SMART ACC: | SM001227 |
| Description: | This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family. This may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation. |
| InterPro ACC: | IPR012891 |
| InterPro abstract: | This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this entry (such as Q9LMF3 … expand |
| Family alignment: | View the Family alignment or the Alignment consensus sequence |
| There are 401 GCK domains in 357 proteins in SMART's NRDB database. | |
Taxonomic distribution of proteins containing GCK domains
The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing GCK domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.
Predicted cellular role
| Cellular role: | Signalling |
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KEGG pathways involving proteins which contain this domain
This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a GCK domain which could be assigned to a KEGG orthologous group, and not all proteins containing GCK domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.