The domain within your query sequence starts at position 258 and ends at position 319; the E-value for the GGL domain shown below is 1.38e-27.



G protein gamma subunit-like motifs
SMART accession number:SM00224
Description: -
Interpro abstract (IPR015898):

This entry represents the G protein gamma subunit and the GGL (G protein gamma-like) domain, which are related in sequence and are comprised of an extended alpha-helical polypeptide. The G protein gamma subunit forms a stable dimer with the beta subunit, but it does not make any contact with the alpha subunit, which contacts the opposite face of the beta subunit. The GGL domain is found in several RGS (regulators of G protein signaling) proteins. GGL domains can interact with beta subunits to form novel dimers that prevent gamma subunit binding, and may prevent heterotrimer formation by inhibiting alpha subunit binding. The interaction between G protein beta-5 neuro-specific isoforms and RGS GGL domains may represent a general mode of binding between beta-propeller proteins and their partners [ (PUBMED:11331068) ].

GO process:G protein-coupled receptor signaling pathway (GO:0007186)
Family alignment:
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There are 4851 GGL domains in 4845 proteins in SMART's nrdb database.

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