The domain within your query sequence starts at position 76 and ends at position 219; the E-value for the IL10 domain shown below is 1.14e-1.

TGVVLPELWEAFWTVKNTVQTQDDITSIRLLKPQVLRNVSGAESCYLAHSLLKFYLNTVF
KNYHSKIAKFKVLRSFSTLANNFIVIMSQLQPSKDNSMLPISESAHQRFLLFRRAFKQLD
TEVALVKAFGEVDILLTWMQKFYH

IL10

Interleukin-10 family

• SMART accession number: SM00188
• Description: Interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.
• Interpro abstract (IPR020443):

  Interleukin-10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds [ (PUBMED:8590020) ]. IL-10 is highly similar to the Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) BCRF1 protein which inhibits the synthesis of gamma-interferon and to Equid herpesvirus 2 (Equine herpesvirus 2) protein E7. It is also similar, but to a lesser degree, with human protein mda-7 [ (PUBMED:8545104) ], a protein which has antiproliferative properties in human melanoma cells. Mda-7 only contains two of the four cysteines of IL-10.

  This entry represents the interleukin-10, interleukin-19, interleukin-20, interleukin-22, interleukin-24 and interleukin-26 family.

There are 1073 IL10 domains in 1072 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
76.67	map04060	Cytokine-cytokine receptor interaction
23.33	map04660	T cell receptor signaling pathway

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with IL10 domain which could be assigned to a KEGG orthologous group, and not all proteins containing IL10 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of IL10 domains in PDB

PDB code	Title
1ilk	INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA
1inr	CYTOKINE SYNTHESIS
1j7v	HUMAN IL-10 / IL-10R1 COMPLEX
1lk3	ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT
1lqs	CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1
1m4r	CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22
1n1f	Crystal Structure of Human Interleukin-19
1vlk	STRUCTURE OF VIRAL INTERLEUKIN-10
1y6k	Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
1y6m	Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain
1y6n	Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
1ykb	Crystal Structure of Insect Cell Expressed IL-22
2h24	Crystal structure of human IL-10
2ilk	CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION
3dgc	Structure of IL-22/IL-22R1
3dlq	Crystal structure of the IL-22/IL-22R1 complex
3g9v	Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
3q1s	HIV-1 neutralizing antibody Z13e1 in complex with epitope display protein
4doh	IL20/IL201/IL20R2 Ternary Complex
4x51	4X51

Links (links to other resources describing this domain)

• PROSITE: INTERLEUKIN_10
• INTERPRO: IPR020443
• PFAM: Interleukin10