The domain within your query sequence starts at position 1193 and ends at position 1290; the E-value for the IPT domain shown below is 7.05e-5.

LTEVFSVEPCSGSLLGGTLLSLLGTGLGRDPALIRVLVDNHPCDIVNLTEVNIWCETPPA
VLPPRADVLTVLASVEIWAGNTSFFHGPSLVGKGFTFT

IPT

ig-like, plexins, transcription factors

• SMART accession number: SM00429
• Description: -
• Interpro abstract (IPR002909):

  The IPT (Ig-like, plexins, transcription factors) domain has an immunoglobulin like fold [ (PUBMED:10390613) ]. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering) [ (PUBMED:8816464) ].

There are 37987 IPT domains in 14790 proteins in SMART's nrdb database.

Literature (relevant references for this domain)

Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

• Aravind L, Koonin EV
• Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches.
• J Mol Biol. 1999; 287: 1023-40

Using a number of diverse protein families as test cases, we investigate the ability of the recently developed iterative sequence database search method, PSI-BLAST, to identify subtle relationships between proteins that originally have been deemed detectable only at the level of structure-structure comparison. We show that PSI-BLAST can detect many, though not all, of such relationships, but the success critically depends on the optimal choice of the query sequence used to initiate the search. Generally, there is a correlation between the diversity of the sequences detected in the first pass of database screening and the ability of a given query to detect subtle relationships in subsequent iterations. Accordingly, a thorough analysis of protein superfamilies at the sequence level is necessary in order to maximize the chances of gleaning non-trivial structural and functional inferences, as opposed to a single search, initiated, for example, with the sequence of a protein whose structure is available. This strategy is illustrated by several findings, each of which involves an unexpected structural prediction: (i) a number of previously undetected proteins with the HSP70-actin fold are identified, including a highly conserved and nearly ubiquitous family of metal-dependent proteases (typified by bacterial O-sialoglycoprotease) that represent an adaptation of this fold to a new type of enzymatic activity; (ii) we show that, contrary to the previous conclusions, ATP-dependent and NAD-dependent DNA ligases are confidently predicted to possess the same fold; (iii) the C-terminal domain of 3-phosphoglycerate dehydrogenase, which binds serine and is involved in allosteric regulation of the enzyme activity, is shown to typify a new superfamily of ligand-binding, regulatory domains found primarily in enzymes and regulators of amino acid and purine metabolism; (iv) the immunoglobulin-like DNA-binding domain previously identified in the structures of transcription factors NFkappaB and NFAT is shown to be a member of a distinct superfamily of intracellular and extracellular domains with the immunoglobulin fold; and (v) the Rag-2 subunit of the V-D-J recombinase is shown to contain a kelch-type beta-propeller domain which rules out its evolutionary relationship with bacterial transposases.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
14.26	map04360	Axon guidance
8.56	map04662	B cell receptor signaling pathway
8.56	map04660	T cell receptor signaling pathway
5.87	map04370	VEGF signaling pathway
5.87	map04310	Wnt signaling pathway
5.87	map04650	Natural killer cell mediated cytotoxicity
5.70	map05120	Epithelial cell signaling in Helicobacter pylori infection
4.19	map05222	Small cell lung cancer
4.19	map04620	Toll-like receptor signaling pathway
4.19	map05212	Pancreatic cancer
4.19	map04210	Apoptosis
4.19	map05220	Chronic myeloid leukemia
4.19	map04920	Adipocytokine signaling pathway
4.19	map05215	Prostate cancer
4.19	map05221	Acute myeloid leukemia
2.68	map04010	MAPK signaling pathway
1.51	map04520	Adherens junction
1.51	map04060	Cytokine-cytokine receptor interaction
1.51	map05210	Colorectal cancer
1.51	map04510	Focal adhesion
1.51	map05211	Renal cell carcinoma
1.51	map05218	Melanoma

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with IPT domain which could be assigned to a KEGG orthologous group, and not all proteins containing IPT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of IPT domains in PDB

PDB code	Title
1a02	STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
1a3q	HUMAN NF-KAPPA-B P52 BOUND TO DNA
1bfs	STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
1bft	STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE
1gji	Crystal structure of c-Rel bound to DNA
1ikn	IKAPPABALPHA/NF-KAPPAB COMPLEX
1imh	TonEBP/DNA COMPLEX
1k3z	X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex
1le5	Crystal structure of a NF-kB heterodimer bound to an IFNb-kB
1le9	Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti
1lei	The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription
1my5	NF-kappaB p65 subunit dimerization domain homodimer
1my7	NF-kappaB p65 subunit dimerization domain homodimer N202R mutation
1nfi	I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX
1nfk	STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
1ooa	CRYSTAL STRUCTURE OF NF-kB(p50)2 COMPLEXED TO A HIGH-AFFINITY RNA APTAMER
1owr	CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA
1oy3	CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX
1p7h	Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element
1pzu	An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site
1qho	FIVE-DOMAIN ALPHA-AMYLASE FROM BACILLUS STEAROTHERMOPHILUS, MALTOSE/ACARBOSE COMPLEX
1qhp	FIVE-DOMAIN ALPHA-AMYLASE FROM BACILLUS STEAROTHERMOPHILUS, MALTOSE COMPLEX
1ram	A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
1s9k	Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
1svc	NFKB P50 HOMODIMER BOUND TO DNA
1u36	Crystal stucture of WLAC mutant of dimerisation domain of NF-kB p50 transcription factor
1u3j	Crystal stucture of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor
1u3y	Crystal stucture of ILAC mutant of dimerisation domain of NF-kB p50 transcription factor
1u3z	Crystal stucture of MLAC mutant of dimerisation domain of NF-kB p50 transcription factor
1u41	Crystal stucture of YLGV mutant of dimerisation domain of NF-kB p50 transcription factor
1u42	Crystal stucture of MLAM mutant of dimerisation domain of NF-kB p50 transcription factor
1vkx	CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA
1zk9	NF-kB RelB forms an intertwined homodimer
1zka	NF-kB RelB forms an intertwined homodimer, Y300S mutant
2as5	Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
2i9t	Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter
2o61	Crystal Structure of NFkB, IRF7, IRF3 bound to the interferon-b enhancer
2o93	Crystal structure of NFAT bound to the HIV-1 LTR tandem kappaB enhancer element
2ram	A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER
2uzx	Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein InlB: Crystal form I
2uzy	Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein inlb: low resolution, Crystal form II
2v2t	X-ray structure of a NF-kB p50-RelB-DNA complex
2yrp	Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4
3do7	X-ray structure of a NF-kB p52/RelB/DNA complex
3gut	Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR
3jss	Crystal structure of a mutant RelB dimerization domain
3juz	Crystal structure of a mutant of RelB dimerization domain(M5)
3jv0	Crystal structure of a mutant of RelB dimerization domain(M6)
3jv4	Crystal structure of the dimerization domains p50 and RelB
3jv5	Crystal structure of the dimerization domains p52 homodimer
3jv6	Crystal structure of the dimerization domains p52 and RelB
3kya	Crystal structure of Putative phosphatase (NP_812416.1) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 1.77 A resolution
3mlp	Early B-cell Factor 1 (Ebf1) bound to DNA
3mqi	Human early B-cell factor 1 (EBF1) IPT/TIG domain
3muj	Early B-cell factor 3 (EBF3) IPT/TIG and dimerization helices
3n50	Human Early B-cell factor 3 (EBF3) IPT/TIG and HLHLH domains
3qrf	Structure of a domain-swapped FOXP3 dimer
3tc9	Crystal structure of a Hypothetical hydrolase (BT_3476) from Bacteroides thetaiotaomicron VPI-5482 at 2.23 A resolution
4hw6	Crystal structure of a hypothetical protein (BACOVA_00264) from Bacteroides ovatus ATCC 8483 at 1.70 A resolution
4jgm	Crystal structure of RelB double mutants: Y300F/I335V
4jhb	Crystal structure of RelB double mutants: Y300F/I335F
4qt8	4QT8
5l56	5L56
5l59	5L59
5l5c	5L5C
5l5g	5L5G
5l5k	5L5K
5l5l	5L5L
5l5m	5L5M
5l5n	5L5N

Links (links to other resources describing this domain)

• INTERPRO: IPR002909