The domain within your query sequence starts at position 151 and ends at position 254; the E-value for the IRS domain shown below is 1.21e-45.

EGSQFWVTSQKTEASERCGLQGSYILRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYG
RDKVMFSFEAGRRCPSGPGTFTFQTSQGNDIFQAVEAAIQQQKA

IRS

Phosphotyrosine-binding domain

• SMART accession number: SM01244
• Description: -

There are 6799 IRS domains in 6794 proteins in SMART's nrdb database.

Structure (3D structures containing this domain)

3D Structures of IRS domains in PDB

PDB code	Title
1irs	IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
1j0w	Crystal Structure Analysis of the Dok-5 PTB Domain
1mix	Crystal structure of a FERM domain of Talin
1miz	Crystal structure of an integrin beta3-talin chimera
1mk7	CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
1mk9	CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
1p5t	Crystal Structure of Dok1 PTB Domain
1qqg	CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
1uef	Crystal Structure of Dok1 PTB Domain Complex
1xr0	Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors
1y19	Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
2dlw	Solution structure of the IRS domain of human docking protein 2, isoform a
2g35	NMR structure of talin-PTB in complex with PIPKI
2h7d	Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide
2h7e	Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure
2k00	Solution structure of the talin F3 in complex with layilin cytodomain
2kgx	HADDOCK structure of the talin F3 domain in complex with talin 1655-1822
2kup	Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK
2kuq	Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK
2mfq	NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB
2mwn	2MWN
2v76	Crystal structure of the human dok1 PTB domain
2ys5	Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK
2yt2	Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK
3g9w	Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail
3ivf	Crystal structure of the talin head FERM domain
3ml4	Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region
4f7g	Crystal structure of talin autoinhibition complex

Links (links to other resources describing this domain)

• PFAM: IRS