The domain within your query sequence starts at position 112 and ends at position 190; the E-value for the LA domain shown below is 2.44e-40.



Domain in the RNA-binding Lupus La protein; unknown function
SMART accession number:SM00715
Description: -
Interpro abstract (IPR006630):

Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome [ (PUBMED:15016896) ]. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor [ (PUBMED:14636586) ]. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation [ (PUBMED:15004549) ]. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis [ (PUBMED:14690589) ]. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [ (PUBMED:15048103) ].

Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [ (PUBMED:7799435) ].

Family alignment:
View or

There are 7892 LA domains in 7878 proteins in SMART's nrdb database.

Click on the following links for more information.