SMART: LamG domain annotation

The domain within your query sequence starts at position 415 and ends at position 554; the E-value for the LamG domain shown below is 2.5e-11.

LEMSNDTGFLSFKDHLPVTQIIISDTNRSNSEAAWRIGPLRCYGDPPSEVIFAIDVGNGP
MELLVQSPYPLNDNQWHYIQAERNIKETLLHVDNLPKSMRMASEEGHFLLQLNSQLFVGG
TSSRQKGFLGCIRSLHLNGQ

LamG Laminin G domain

SMART accession number:	SM00282
Description:	-
Family alignment:	View or

There are 74121 LamG domains in 31952 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing LamG domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LamG domain is also avaliable.

Click on the protein counts, or double click on taxonomic names to display all proteins containing LamG domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Beckmann G, Hanke J, Bork P, Reich JG
- Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins.
- J Mol Biol. 1998; 275: 725-30
- Display abstract
- Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. Thus, we predict a similar jellyroll fold for all members of this superfamily. In addition, the conservation of two exposed aspartate residues in the majority of superfamily members suggests hitherto unrecognised functional sites.
Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the LamG domain.

Protein Disease

Laminin subunit alpha-2 (P24043) (SMART) OMIM:156225: Muscular dystrophy, congenital merosin-deficient
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

Protein	Disease
Laminin subunit alpha-2 (P24043) (SMART)	OMIM:156225: Muscular dystrophy, congenital merosin-deficient

3D Structures of LamG domains in PDB

PDB code	Main view	Title
1c4r		THE STRUCTURE OF THE LIGAND-BINDING DOMAIN OF NEUREXIN 1BETA: REGULATION OF LNS DOMAIN FUNCTION BY ALTERNATIVE SPLICING
1d2s		CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE
1dyk		Laminin alpha 2 chain LG4-5 domain pair
1f5f		CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC
1h30		C-terminal LG domain pair of human Gas6
1kdk		THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA
1kdm		THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)
1lhn		CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL
1lho		CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL
1lhu		CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL
1lhv		CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL
1lhw		CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL
1okq		LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT
1pz7		Modulation of agrin function by alternative splicing and Ca2+ binding
1pz8		Modulation of agrin function by alternative splicing and Ca2+ binding
1pz9		Modulation of agrin function by alternative splicing and Ca2+ binding
1q56		NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state
1qu0		CRYSTAL STRUCTURE OF THE FIFTH LAMININ G-LIKE MODULE OF THE MOUSE LAMININ ALPHA2 CHAIN
1sli		LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH DANA
1sll		SIALIDASE L FROM LEECH MACROBDELLA DECORA
2c5d		Structure of a minimal Gas6-Axl complex
2h0b		Crystal Structure of the second LNS/LG domain from Neurexin 1 alpha
2jd4		Mouse laminin alpha1 chain, domains LG4-5
2r16		Crystal Structure of bovine neurexin 1 alpha LNS/LG domain 4 (with no splice insert)
2r1b		Crystal Structure of rat neurexin 1beta with a splice insert at SS#4
2r1d		Crystal structure of rat neurexin 1beta in the Ca2+ containing form
2sli		LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC, THE REACTION PRODUCT
2wjs		Crystal structure of the LG1-3 region of the laminin alpha2 chain
2wqz		Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement
2xb6		Revisited crystal structure of Neurexin1beta-Neuroligin4 complex
3asi		Alpha-Neurexin-1 ectodomain fragment; LNS5-EGF3-LNS6
3b3q		Crystal structure of a synaptic adhesion complex
3biw		Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex
3bod		Structure of mouse beta-neurexin 1
3bop		Structure of mouse beta-neurexin 2D4
3mw2		Crystal structure of beta-neurexin 1 with the splice insert 4
3mw3		Crystal structure of beta-neurexin 2 with the splice insert 4
3mw4		Crystal structure of beta-neurexin 3 without the splice insert 4
3poy		Crystal Structure of the alpha-Neurexin-1 ectodomain, LNS 2-6
3pve		Crystal structure of the G2 domain of Agrin from Mus Musculus
3qcw		Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts
3r05		Structure of neurexin 1 alpha (domains LNS1-LNS6), with splice insert SS3
3sh4		Laminin G like domain 3 from human perlecan
3sh5		Calcium-bound Laminin G like domain 3 from human perlecan
3sli		LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2,7-ANHYDRO-NEU5AC PREPARED BY SOAKING WITH 3'-SIALYLLACTOSE
3v64		Crystal Structure of agrin and LRP4
3v65		Crystal structure of agrin and LRP4 complex
3vkf		Crystal Structure of Neurexin 1beta/Neuroligin 1 complex
4c1w		4C1W
4c1x		4C1X
4qvs		4QVS
4ra0		4RA0
4sli		LEECH INTRAMOLECULAR TRANS-SIALIDASE COMPLEXED WITH 2-PROPENYL-NEU5AC, AN INACTIVE SUBSTRATE ANALOGUE
4zxk		4ZXK
5ik4		5IK4
5ik5		5IK5
5ik7		5IK7
5ik8		5IK8

Links (links to other resources describing this domain)
PFAM laminin_G

The domain within your query sequence starts at position 415 and ends at position 554; the E-value for the LamG domain shown below is 2.5e-11.

LamG

Taxonomic distribution of proteins containing LamG domain.

3D Structures of LamG domains in PDB