NEAT

NEAr Transporter domain

• SMART accession number: SM00725
• Description: -
• Interpro abstract (IPR006635):

  This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone [ (PUBMED:12823809) ]. In Staphylococcus aureus, isdH protein contains three NEAT (NEAr Transporter) domains: IsdH(N1), IsdH(N2), and IsdH(N3). These three domains have different functions, IsdH(N1) binds hemoglobin and haptoglobin, whereas IsdH(N3) captures heme that is released from hemoglobin [ (PUBMED:18984582) (PUBMED:16762363) ].

There are 5397 NEAT domains in 2292 proteins in SMART's nrdb database.

Structure (3D structures containing this domain)

3D Structures of NEAT domains in PDB

PDB code	Title
2e7d	Crystal structure of a NEAT domain from Staphylococcus aureus
2h3k	Solution Structure of the first NEAT domain of IsdH
2ite	Crystal structure of the IsdA NEAT domain from Staphylococcus aureus
2itf	Crystal structure IsdA NEAT domain from Staphylococcus aureus with heme bound
2k78	Solution Structure of the IsdC NEAT domain bound to Zinc Protoporphyrin
2moq	2MOQ
2o1a	Crystal structure of iron-regulated surface determinant protein A from Staphylococcus aureus- targeted domain 47...188
2o6p	Crystal Structure of the heme-IsdC complex
2z6f	Crystal structure of NEAT domain from Staphylococcus aureus in complex with heme
3ovu	Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus
3qug	Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Gallium-porphyrin
3quh	Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Manganese(III)-porphyrin
3qzl	Staphylococcus aureus IsdA NEAT domain K75A variant in complex with heme
3qzm	Staphylococcus aureus IsdA NEAT domain H83A variant in complex with heme
3qzn	Staphylococcus aureus IsdA NEAT domain Y166A variant in complex with heme
3qzo	Staphylococcus aureus IsdA NEAT domain in complex with heme, reduced crystal
3qzp	Staphylococcus aureus IsdA NEAT domain in complex with cobalt-protoporphyrin IX
3rtl	Staphylococcus aureus heme-bound IsdB-N2
3rur	Staphylococcus aureus heme-bound selenomethionine-labeled IsdB-N2
3s48	Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus
3sik	Crystal structure of the Bacillus anthracis hemophore IsdX1 complexed with heme
3sz6	IsdX1, an anthrax hemophore
3szk	Crystal Structure of Human metHaemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus
3vtm	Structure of heme transport protein IsdH-NEAT3 from S. aureus in complex with Indium-porphyrin
3vua	Apo IsdH-NEAT3 in space group P3121 at a resolution of 1.85 A
4fc3	Crystal Structure of Human Methaemoglobin Complexed with the Second NEAT Domain of IsdH from Staphylococcus aureus
4h8p	NEAT5 domain of IsdX2, a B. anthracis hemophore in complex with heme
4h8q	Structure of the Q29T IsdX2-NEAT5 mutant in complex with heme
4ij2	Human methemoglobin in complex with the second and third NEAT domains of IsdH from Staphylococcus aureus
4myp	4MYP
4nla	4NLA
4wjg	4WJG
4xs0	4XS0
4ymp	4YMP
5d1q	5D1Q
5d1x	5D1X
5d1z	5D1Z

Links (links to other resources describing this domain)

• INTERPRO: IPR006635