OSTEO Osteopontin
SMART ACC:	SM000017
Description:	Osteopontin is an acidic phosphorylated glycoprotein of about 40 Kd which is abundant in the mineral matrix of bones and which binds tightly to hydroxyapatite [1,2,3]. It is suggested that osteopontin might function as a cell attachment factor and could play a key role in the adhesion of osteoclasts to the mineral matrix of bone
InterPro ACC:	IPR002038
InterPro abstract:	The major event of endochondrial ossification is the proteolytic degradation of calcified cartilage and the extracellular matrix, and theirsubstitution with bone-specific extracellular matrix produced and organised by osteoblasts [ PUBMED:2033080 ]. One of the most abundant products of osteoblasts is osteopontin, a glycosylated … expand The major event of endochondrial ossification is the proteolytic degradation of calcified cartilage and the extracellular matrix, and theirsubstitution with bone-specific extracellular matrix produced and organised by osteoblasts [ PUBMED:2033080 ]. One of the most abundant products of osteoblasts is osteopontin, a glycosylated phosphoprotein with a high acidic amino acid content and one copy of the cell attachment sequence RGD [ PUBMED:2033080 ]. It is thought that osteopontin may act as a bridge between osteoblasts and the apatite mineral of the bone [ PUBMED:2033080 ]. Osteopontin-K is a kidney protein, similar to osteopontin and probably also involved in cell adhesion [ PUBMED:1414488 ]. collapse
GO process:	ossification (GO:0001503), cell adhesion (GO:0007155)
Family alignment:	View the Family alignment or the Alignment consensus sequence
There are 184 OSTEO domains in 184 proteins in SMART's NRDB database.

Taxonomic distribution of proteins containing OSTEO domains

The tree below includes only several representative species and genera. The complete taxonomic breakdown of all proteins containing OSTEO domains can be accessed here. Click the counts or percentage values to display the corresponding proteins.

Relevant references for this domain

Primary literature for the OSTEO domain is listed below. Automatically-derived, secondary literature is also available.

KEGG pathways involving proteins which contain this domain

This information is based on the mapping of SMART genomic protein database to KEGG orthologous groups. Percentages are related to the number of proteins containing a OSTEO domain which could be assigned to a KEGG orthologous group, and not all proteins containing OSTEO domains. Please note that proteins can be included in multiple pathways, ie. the numbers below will not add to 100%.

KEGG pathways

KEGG orthologous groups

Links to other resources describing this domain

InterPro	IPR002038