The domain within your query sequence starts at position 115 and ends at position 328; the E-value for the Pept_C1 domain shown below is 4.25e-112.

WARNING!
Some of the required catalytic sites were not detected in this domain. It is probably inactive! Check the literature (PubMed 20480081 ) for details.

Catalytic residues
Position		Amino acid	Present?
Domain	Protein
17	131	Q	No
23	137	C	No
N/A	N/A	H	No

VPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTEN
YGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKA
LKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWII
KNSWGESWGNKGYALLARNKNNACGITNMASFPK

Pept_C1

Papain family cysteine protease

• SMART accession number: SM00645
• Description: -
• Interpro abstract (IPR000668):

  This group of proteins belong to the cysteine peptidase family C1, sub-family C1A (papain family, clan CA).

  The papain family has a wide variety of activities, including broad-range (papain) and narrow-range endo-peptidases, aminopeptidases, carboxypeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity [ (PUBMED:7845226) ]. Members of the papain family are widespread, found in bacteria, archaea, fungi, and practically all protozoa, plants and mammals [ (PUBMED:7845226) ], and some viruses such as baculoviruses [ (PUBMED:1363350) ]. The proteins are typically lysosomal or secreted. The catalytic residues of papain are Cys-25 and His-159, other important residues being Gln-19, which helps form the 'oxyanion hole', and Asn-175, which orientates the imidazole ring of His-159. Most papain-like cysteine peptidases are irreversibly inhibited by the synthetic inhibitor E64 [ (PUBMED:7044372) ]. Leupeptin is a reversible inhibitor but is also an inhibitor of chymotrypsin-like serine peptidases.

  A papain-like cysteine proteinase is typically synthesised as an inactive precursor (or zymogen) with an N-terminal propeptide. Activation requires removal of the propeptide. The propeptide is required for the proper folding of the newly synthesised enzyme, maintaining the peptidase in an inactive state and stabilisation of the enzyme against denaturing at neutral to alkaline pH conditions. Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme to lysosomes. A propeptide can exhibit high selectivity for inhibition of the peptidase from which it originates [ (PUBMED:12188906) ].

  The subfamily includes the following well characterised peptidases:

  • Animal lysosomal peptidases such as cathepsins B (EC 3.4.22.1), L (EC 3.4.22.15), H (EC 3.4.22.16), S (EC 3.4.22.27), K (EC 3.4.22.38), F (EC 3.4.22.41), O (EC 3.4.22.42), V (EC 3.4.22.43) and X (a carboxypeptidase, EC 3.4.18.1).
  • Plant peptidases such as papain (EC 3.4.22.2), ficin (EC 3.4.22.3), chymopapain (EC 3.4.22.6), asclepain A (EC 3.4.22.7), actinidin (EC 3.4.22.14), glycyl endopeptidase (EC 3.4.22.25), caricain (EC 3.4.22.30), ananain (EC 3.4.22.31), stem bromelain (EC 3.4.22.32 and fruit bromelain (EC 3.4.22.33).
  • Protozoan peptidases such as histolysain (EC 3.4.22.35) and cruzipain (EC 3.4.22.51).
  • Viral peptidases such as V-cath (EC 3.4.22.50).

  There are also proteins in the family that are not peptidases because one or more of the active site residues is not conserved. These include testin, tubulointerstitial nephritis antigen and silicatein.

  Cysteine peptidases with a chymotrypsin-like fold are included in clan PA, which also includes serine peptidases. Cysteine peptidases that are N-terminal nucleophile hydrolases are included in clan PB. Cysteine peptidases with a tertiary structure similar to that of the serine-type aspartyl dipeptidase are included in clan PC. Cysteine peptidases with an intein-like fold are included in clan PD, which also includes asparagine lyases.

  A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families [ (PUBMED:11517925) ]. Clans CF, CM, CN, CO, CP and PD contain only one family.

  Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N -ethylmaleimide or p -chloromercuribenzoate.

  Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a beta-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [ (PUBMED:7044372) ].

  Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an alpha/beta/alpha sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues [ (PUBMED:9891971) ]. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.

  Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a beta barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.

  Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed beta barrel decorated with helices with the active site at one end of the barrel [ (PUBMED:14725770) ]. The active site consists of a His/Cys catalytic dyad.

• GO process: proteolysis (GO:0006508)
• GO function: cysteine-type peptidase activity (GO:0008234)

There are 19688 Pept_C1 domains in 19347 proteins in SMART's nrdb database.

Metabolism (metabolic pathways involving proteins which contain this domain)

% proteins involved	KEGG pathway ID	Description
100.00	map04612	Antigen processing and presentation

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Pept_C1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Pept_C1 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

Structure (3D structures containing this domain)

3D Structures of Pept_C1 domains in PDB

PDB code	Title
1aec	CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+
1aim	CRUZAIN INHIBITED BY BENZOYL-TYROSINE-ALANINE-FLUOROMETHYLKETONE
1atk	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64
1au0	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC DIACYLAMINOMETHYL KETONE INHIBITOR
1au2	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PROPANONE INHIBITOR
1au3	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR
1au4	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR
1ayu	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT SYMMETRIC BISCARBOHYDRAZIDE INHIBITOR
1ayv	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT THIAZOLHYDRAZIDE INHIBITOR
1ayw	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT BENZYLOXYBENZOYLCARBOHYDRAZIDE INHIBITOR
1bgo	CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR
1bp4	USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.
1bqi	USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.
1by8	THE CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN K
1cjl	CRYSTAL STRUCTURE OF A CYSTEINE PROTEASE PROFORM
1cpj	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
1cqd	THE 2.1 ANGSTROM STRUCTURE OF A CYSTEINE PROTEASE WITH PROLINE SPECIFICITY FROM GINGER RHIZOME, ZINGIBER OFFICINALE
1cs8	CRYSTAL STRUCTURE OF PROCATHEPSIN L
1csb	CRYSTAL STRUCTURE OF CATHEPSIN B INHIBITED WITH CA030 AT 2.1 ANGSTROMS RESOLUTION: A BASIS FOR THE DESIGN OF SPECIFIC EPOXYSUCCINYL INHIBITORS
1cte	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
1cvz	CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)
1deu	CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINE PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVE SITE CYSTEINE
1ef7	CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X
1ewl	CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99
1ewm	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112
1ewo	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204
1ewp	CRUZAIN BOUND TO MOR-LEU-HPQ
1f29	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I)
1f2a	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II)
1f2b	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III)
1f2c	CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV)
1fh0	CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR
1gec	GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25
1glo	Crystal Structure of Cys25Ser mutant of human cathepsin S
1gmy	Cathepsin B complexed with dipeptidyl nitrile inhibitor
1huc	THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY
1icf	CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L
1ito	Crystal Structure Analysis of Bovine Spleen Cathepsin B-E64c complex
1iwd	Proposed Amino Acid Sequence and the 1.63 Angstrom X-ray Crystal Structure of a Plant Cysteine Protease Ervatamin B: Insight into the Structural Basis of its Stability and Substrate Specificity.
1jqp	dipeptidyl peptidase I (cathepsin C), a tetrameric cysteine protease of the papain family
1k3b	Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases
1khp	Monoclinic form of papain/ZLFG-DAM covalent complex
1khq	ORTHORHOMBIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX
1m6d	Crystal structure of human cathepsin F
1me3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)
1me4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)
1meg	CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64
1mem	CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR
1mhw	Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
1mir	RAT PROCATHEPSIN B
1ms6	Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
1nb3	Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases
1nb5	Crystal structure of stefin A in complex with cathepsin H
1nl6	Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor
1nlj	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR
1npz	Crystal structures of Cathepsin S inhibitor complexes
1nqc	Crystal structures of Cathepsin S inhibitor complexes
1o0e	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C
1pad	BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
1pbh	CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION
1pci	PROCARICAIN
1pe6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION
1pip	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS
1pop	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX
1ppd	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS
1ppn	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION
1ppo	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA
1ppp	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES
1q6k	Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
1qdq	X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX
1s4v	The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm
1snk	Cathepsin K complexed with carbamate derivatized norleucine aldehyde
1sp4	Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft
1stf	THE REFINED 2.4 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF RECOMBINANT HUMAN STEFIN B IN COMPLEX WITH THE CYSTEINE PROTEINASE PAPAIN: A NOVEL TYPE OF PROTEINASE INHIBITOR INTERACTION
1the	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
1tu6	Cathepsin K complexed with a ketoamide inhibitor
1u9q	Crystal structure of cruzain bound to an alpha-ketoester
1u9v	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854
1u9w	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491
1u9x	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688
1vsn	Crystal structure of a potent small molecule inhibitor bound to cathepsin K
1xkg	Crystal structure of the major house dust mite allergen Der p 1 in its pro form at 1.61 A resolution
1yal	CARICA PAPAYA CHYMOPAPAIN AT 1.7 ANGSTROMS RESOLUTION
1yk7	Cathepsin K complexed with a cyanopyrrolidine inhibitor
1yk8	Cathepsin K complexed with a cyanamide-based inhibitor
1yt7	Cathepsin K complexed with a constrained ketoamide inhibitor
1yvb	the Plasmodium falciparum Cysteine Protease Falcipain-2
2act	CRYSTALLOGRAPHIC REFINEMENT OF THE STRUCTURE OF ACTINIDIN AT 1.7 ANGSTROMS RESOLUTION BY FAST FOURIER LEAST-SQUARES METHODS
2aim	CRUZAIN INHIBITED WITH BENZOYL-ARGININE-ALANINE-FLUOROMETHYLKETONE
2as8	Crystal structure of mature and fully active Der p 1 allergen
2ato	Crystal structure of Human Cathepsin K in complex with myocrisin
2aux	Cathepsin K complexed with a semicarbazone inhibitor
2auz	Cathepsin K complexed with a semicarbazone inhibitor
2b1m	Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus
2b1n	Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus
2bdl	Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor
2bdz	Mexicain from Jacaratia mexicana
2c0y	THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S
2cio	The high resolution x-ray structure of papain complexed with fragments of the Trypanosoma brucei cysteine protease inhibitor ICP.
2dc6	X-ray crystal structure analysis of bovine spleen cathepsin B-CA073 complex
2dc7	X-ray crystal structure analysis of bovine spleen cathepsin B-CA042 complex
2dc8	X-ray crystal structure analysis of bovine spleen cathepsin B-CA059 complex
2dc9	X-ray crystal structure analysis of bovine spleen cathepsin B-CA074Me complex
2dca	X-ray crystal structure analysis of bovine spleen cathepsin B-CA075 complex
2dcb	X-ray crystal structure analysis of bovine spleen cathepsin B-CA076 complex
2dcc	X-ray crystal structure analysis of bovine spleen cathepsin B-CA077 complex
2dcd	X-ray crystal structure analysis of bovine spleen cathepsin B-CA078 complex
2djf	Crystal Structure of human dipeptidyl peptidase I (Cathepsin C) in complex with the inhibitor Gly-Phe-CHN2
2djg	Re-determination of the native structure of human dipeptidyl peptidase I (cathepsin C)
2f1g	Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide
2f7d	A mutant rabbit cathepsin K with a nitrile inhibitor
2fo5	Crystal structure of recombinant barley cysteine endoprotease B isoform 2 (EP-B2) in complex with leupeptin
2fq9	Cathepsin S with nitrile inhibitor
2fra	Human Cathepsin S with CRA-27934, a Nitrile Inhibitor
2frq	Human Cathepsin S with Inhibitor CRA-26871
2ft2	Human Cathepsin S with Inhibitor CRA-29728
2ftd	Crystal structure of Cathepsin K complexed with 7-Methyl-Substituted Azepan-3-one compound
2fud	Human Cathepsin S with Inhibitor CRA-27566
2fye	Mutant Human Cathepsin S with irreversible inhibitor CRA-14013
2g6d	Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009
2g7y	Human Cathepsin S with inhibitor CRA-16981
2ghu	Crystal structure of falcipain-2 from Plasmodium falciparum
2h7j	Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor.
2hh5	Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide
2hhn	Cathepsin S in complex with non covalent arylaminoethyl amide.
2hxz	Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)
2ipp	Crystal Structure of the tetragonal form of human liver cathepsin B
2nqd	Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L
2o6x	Crystal Structure of ProCathepsin L1 from Fasciola hepatica
2op3	The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method
2oul	The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family
2oz2	Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)
2p7u	The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777
2p86	The high resolution crystal structure of rohedsain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002
2pad	BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
2pbh	CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION
2pns	1.9 Angstrom resolution crystal structure of a plant cysteine protease Ervatamin-C refinement with cDNA derived amino acid sequence
2pre	Crystal structure of plant cysteine protease Ervatamin-C complexed with irreversible inhibitor E-64 at 2.7 A resolution
2r6n	Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K
2r9m	Cathepsin S complexed with Compound 15
2r9n	Cathepsin S complexed with Compound 26
2r9o	Cathepsin S complexed with Compound 8
2vhs	Cathsilicatein, a chimera
2wbf	Crystal Structure Analysis of SERA5E from plasmodium falciparum with loop 690-700 ordered
2xu1	CATHEPSIN L WITH A NITRILE INHIBITOR
2xu3	CATHEPSIN L WITH A NITRILE INHIBITOR
2xu4	CATHEPSIN L WITH A NITRILE INHIBITOR
2xu5	CATHEPSIN L WITH A NITRILE INHIBITOR
2yj2	CATHEPSIN L WITH A NITRILE INHIBITOR
2yj8	CATHEPSIN L WITH A NITRILE INHIBITOR
2yj9	CATHEPSIN L WITH A NITRILE INHIBITOR
2yjb	CATHEPSIN L WITH A NITRILE INHIBITOR
2yjc	CATHEPSIN L WITH A NITRILE INHIBITOR
3ai8	Cathepsin B in complex with the nitroxoline
3bc3	Exploring inhibitor binding at the S subsites of cathepsin L
3bcn	Crystal structure of a papain-like cysteine protease Ervatamin-A complexed with irreversible inhibitor E-64
3bpf	Crystal Structure of Falcipain-2 with Its inhibitor, E64
3bpm	Crystal Structure of Falcipain-3 with Its inhibitor, Leupeptin
3bwk	Crystal Structure of Falcipain-3 with Its inhibitor, K11017
3c9e	Crystal structure of the cathepsin K : chondroitin sulfate complex.
3cbj	Chagasin-Cathepsin B complex
3cbk	chagasin-cathepsin B
3ch2	Crystal Structure Analysis of SERA5E from plasmodium falciparum
3ch3	Crystal Structure Analysis of SERA5E from plasmodium falciparum
3d6s	Crystal structure of mite allergen Der f 1
3e1z	Crystal structure of the parasite protesase inhibitor chagasin in complex with papain
3f5v	C2 Crystal form of mite allergen DER P 1
3f75	Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide
3h6s	Strucure of clitocypin - cathepsin V complex
3h7d	The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate
3h89	A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 4)
3h8b	A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9)
3h8c	A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors (compound 14)
3hd3	High resolution crystal structure of cruzain bound to the vinyl sulfone inhibitor SMDC-256047
3hha	Crystal structure of cathepsin L in complex with AZ12878478
3hhi	Crystal Structure of Cathepsin B from T. brucei in complex with CA074
3hwn	CATHEPSIN L with AZ13010160
3i06	Crystal structure of cruzain covalently bound to a purine nitrile
3iej	Pyrazole-based Cathepsin S Inhibitors with Arylalkynes as P1 Binding Elements
3ima	Complex strcuture of tarocystatin and papain
3ioq	Crystal structure of the Carica candamarcensis cysteine protease CMS1MS2 in complex with E-64.
3iut	The Crystal Structure of Cruzain in Complex with a Tetrafluorophenoxymethyl Ketone Inhibitor
3iv2	Crystal structure of mature apo-Cathepsin L C25A mutant
3k24	Crystal structure of mature apo-Cathepsin L C25A mutant in complex with Gln-Leu-Ala peptide
3k9m	Cathepsin B in complex with stefin A
3kfq	Unreduced cathepsin V in complex with stefin A
3kku	Cruzain in complex with a non-covalent ligand
3kse	Unreduced cathepsin L in complex with stefin A
3kw9	X-ray structure of Cathepsin K covalently bound to a triazine ligand
3kwb	Structure of CatK covalently bound to a dioxo-triazine inhibitor
3kwn	Cathepsin S in complex with Thioether Acetamide P3 inhibitor
3kwz	Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor
3kx1	Cathepsin K in complex with a selective 2-cyano-pyrimidine inhibitor
3lfy	CTD of Tarocystatin in complex with papain
3lxs	Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (WRR483)
3mor	Crystal structure of Cathepsin B from Trypanosoma Brucei
3mpe	Crystal structure of human Cathepsin-S C25S mutant with bound drug
3mpf	Crystal structure of human Cathepsin-S C25S mutant with bound drug
3n3g	4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
3n4c	6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
3o0u	Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG
3o1g	Cathepsin K covalently bound to a 2-cyano pyrimidine inhibitor with a benzyl P3 group.
3of8	Structural Basis for Reversible and Irreversible Inhibition of Human Cathepsin L by their Respective Dipeptidyl Glyoxal and Diazomethylketone Inhibitors
3of9	Structural Basis for Irreversible Inhibition of Human Cathepsin L by a Diazomethylketone Inhibitor
3ois	Crystal Structure Xylellain, a cysteine protease from Xylella fastidiosa
3ovx	Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead
3ovz	Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead
3p5u	Actinidin from Actinidia arguta planch (Sarusashi)
3p5v	Actinidin from Actinidia arguta planch (Sarusashi)
3p5w	Actinidin from Actinidia arguta planch (Sarusashi)
3p5x	Actinidin from Actinidia arguta planch (Sarusashi)
3pbh	REFINED CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 2.5 ANGSTROM RESOLUTION
3pdf	Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C
3pnr	Structure of PbICP-C in complex with falcipain-2
3qj3	Structure of digestive procathepsin L2 proteinase from Tenebrio molitor larval midgut
3qsd	Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor
3qt4	Structure of digestive procathepsin L 3 of Tenebrio molitor larval midgut
3rvv	Crystal structure of Der f 1 complexed with Fab 4C1
3rvw	Crystal structure of Der p 1 complexed with Fab 4C1
3rvx	Crystal structure of Der p 1 complexed with Fab 4C1
3s3q	Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor
3s3r	Structure of cathepsin B1 from Schistosoma mansoni in complex with K11777 inhibitor
3tnx	Structure of the precursor of a thermostable variant of papain at 2.6 Angstroem resolution
3u8e	Crystal Structure of Cysteine Protease from Bulbs of Crocus sativus at 1.3 A Resolution
3usv	Structure of the precursor of a thermostable variant of papain at 3.8 A resolution from a crystal soaked at pH 4
4axl	HUMAN CATHEPSIN L APO FORM WITH ZN
4axm	TRIAZINE CATHEPSIN INHIBITOR COMPLEX
4bpv	4BPV
4bqv	4BQV
4bs5	MOUSE CATHEPSIN S WITH COVALENT LIGAND
4bs6	4BS6
4bsq	MOUSE CATHEPSIN S WITH COVALENT LIGAND
4cdc	Human DPP1 in complex with (2S)-2-amino-N-((1S)-1-cyano-2-(4- phenylphenyl)ethyl)butanamide
4cdd	Human DPP1 in complex with (2S)-N-((1S)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide
4cde	Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide
4cdf	Human DPP1 in complex with (2S,4S)-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)-4-hydroxy-piperidine-2-carboxamide
4ci7	The crystal structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer associated protein of Clostridium difficile
4d59	4D59
4d5a	4D5A
4dmx	Cathepsin K inhibitor
4dmy	Cathepsin K inhibitor
4hwy	Trypanosoma brucei procathepsin B solved from 40 fs free-electron laser pulse data by serial femtosecond X-ray crystallography
4i04	Structure of zymogen of cathepsin B1 from Schistosoma mansoni
4i05	Structure of intermediate processing form of cathepsin B1 from Schistosoma mansoni
4i07	Structure of mature form of cathepsin B1 from Schistosoma mansoni
4klb	Crystal Structure of Cruzain in complex with the non-covalent inhibitor Nequimed176
4kp9	4KP9
4mzo	4MZO
4mzs	4MZS
4n4z	Trypanosoma brucei procathepsin B structure solved by Serial Microcrystallography using synchrotron radiation
4n79	4N79
4n8w	4N8W
4oel	4OEL
4oem	4OEM
4p6e	4P6E
4p6g	4P6G
4pad	BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
4pi3	4PI3
4pp1	4PP1
4pp2	4PP2
4qh6	4QH6
4qrg	4QRG
4qrv	4QRV
4qrx	4QRX
4w5b	4W5B
4w5c	4W5C
4x6h	4X6H
4x6i	4X6I
4x6j	4X6J
4xui	4XUI
4yv8	4YV8
4yva	4YVA
4yyq	4YYQ
4yyr	4YYR
4yys	4YYS
4yyu	4YYU
4yyv	4YYV
4yyw	4YYW
5a24	5A24
5ef4	5EF4
5egw	5EGW
5f02	5F02
5fpw	5FPW
5i4h	5I4H
5j94	5J94
5ja7	5JA7
5jh3	5JH3
5pad	BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
6pad	BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
7pck	CRYSTAL STRUCTURE OF WILD TYPE HUMAN PROCATHEPSIN K
8pch	CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION
9pap	STRUCTURE OF PAPAIN REFINED AT 1.65 ANGSTROMS RESOLUTION

Links (links to other resources describing this domain)

• PFAM: Peptidase_C1
• INTERPRO: IPR000668