The domain within your query sequence starts at position 416 and ends at position 704; the E-value for the ALIX_LYPXL_bnd domain shown below is 1.4e-64.
HIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELQEQKLQE TLGQAGAGPGPSVAKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPL DQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTT DHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDNVLRALTEANVQYAAVRRVLSELDQKWNS TLQTLVASYEAYEDLMKKSQEGKDFYADLESKVATLLERAQSICRAQEA
ALIX_LYPXL_bnd |
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PFAM accession number: | PF13949 |
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Interpro abstract (IPR025304): | The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [ (PUBMED:17350572) (PUBMED:17277784) ]. Retroviruses thus used this domain to hijack the ESCRT system of the cell [ (PUBMED:18066081) ]. |
GO function: | protein binding (GO:0005515) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry ALIX_LYPXL_bnd