The domain within your query sequence starts at position 24 and ends at position 298; the E-value for the AP1AR domain shown below is 3.5e-152.
GGGSKYFRTCPRGEHLTIEFENLVESDEGESPGSSHRPLTEDEIADLQERHYDSIAEKQK DVDRKIQRQLALQEEKLRLEEEALYAAQREAARAARQRKLLEQEKQRVAQHYHCSSGDYQ SAGPEDDFESSLRNIKSQYEVFRSSRLSSDATVLTPNTESSCDLMTKTKSTSGNDDSTSL DLEWEDEEGMNRMLPMRERSKTEEDILRAALKYSSKKGSNPTSASDDSNGLEWENDFVSA EMDDNGNSEYSGFVNPVLELSDSAIKQSDTDQQIR
AP1AR |
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PFAM accession number: | PF15745 |
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Interpro abstract (IPR031483): | AP-1 complex-associated regulatory protein (AP1AR), also known as gadkin or gamma-BAR, is a negative regulator of the actin-related protein (ARP)2/3 complex, a major regulator of actin dynamics. Through inhibition of ARP2/3, gadkin negatively regulates cell spreading and motility [ (PUBMED:22689987) ]. Gadkin is also a modulator of adaptor protein (AP)-1-mediated endosomal membrane trafficking [ (PUBMED:15775984) (PUBMED:19965873) (PUBMED:21525240) ]. |
GO process: | vesicle targeting, trans-Golgi to endosome (GO:0048203), negative regulation of cell motility (GO:2000146), regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315), negative regulation of substrate adhesion-dependent cell spreading (GO:1900025) |
GO function: | AP-1 adaptor complex binding (GO:0035650) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry AP1AR