The domain within your query sequence starts at position 111 and ends at position 354; the E-value for the Aminotran_4 domain shown below is 5.9e-26.



PFAM accession number:PF01063
Interpro abstract (IPR001544):

Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [ (PUBMED:1644759) ] into subfamilies.

This entry represents a subfamily of aminotransferases, called class-IV, with currently consists of proteins of about 270 to 415 amino-acid residues that share a few regions of sequence similarity. Surprisingly, the best conserved region does not include the lysine residue to which the pyridoxal-phosphate group is known to be attached, in ilvE, but is located some 40 residues at the C terminus side of the pyridoxal-phosphate-lysine. The D-amino acid transferases (D-AAT), which are among the members of this entry, are required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity [ (PUBMED:7626635) (PUBMED:9163511) ].

This group also includes transaminase htyB from Aspergillus rugulosus which is one of the enzymes required for the biosynthesis of the antifungal agent echinocandin B. HtyB catalyses the production of L-homotyrosine from the intermediate 2-oxo-4-(4-hydroxybenzyl)butanoic acid [ (PUBMED:22998630) ]. Also included in this group is branched-chain amino acid aminotransferase gloG from the yeast Glarea lozoyensis which is required for biosynthesis of the mycotoxin pneumocandin, also a lipohexapeptide of the echinocandin family [ (PUBMED:27705900) ].

GO function:catalytic activity (GO:0003824)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Aminotran_4