The domain within your query sequence starts at position 8 and ends at position 403; the E-value for the Arginosuc_synth domain shown below is 1.1e-178.
VLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSKE FVEEFIWPAVQSSALYEDRYLLGTSLARPCIARRQVEIAQREGAKYVSHGATGKGNDQVR FELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVSPKSPWSMDENLMH ISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDVLEIEFKKGVPVKVTNIKDGTTRTTS LELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVR KIKQGLGLKFAELVYTGFWHSPECEFVRHCIQKSQERVEGKVQVSVFKGQVYILGRESPL SLYNEELVSMNVQGDYEPIDATGFININSLRLKEYH
Arginosuc_synth |
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PFAM accession number: | PF00764 |
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Interpro abstract (IPR001518): | Argininosuccinate synthase ( EC 6.3.4.5 ) (AS) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate [ (PUBMED:2123815) (PUBMED:3133361) ]. In humans, a defect in the AS gene causes citrullinemia, a genetic disease characterised by severe vomiting spells and mental retardation. AS is a homotetrameric enzyme of chains of about 400 amino-acid residues. An arginine seems to be important for the enzyme's catalytic mechanism. The sequences of AS from various prokaryotes, archaebacteria and eukaryotes show significant similarity. |
GO process: | arginine biosynthetic process (GO:0006526) |
GO function: | argininosuccinate synthase activity (GO:0004055), ATP binding (GO:0005524) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Arginosuc_synth