The domain within your query sequence starts at position 68 and ends at position 214; the E-value for the BCDHK_Adom3 domain shown below is 1.4e-43.



PFAM accession number:PF10436
Interpro abstract (IPR018955):

Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. Regulating the activity of the branched-chain alpha-ketoacid dehydrogenase (BCDH) complex is the primary means by which these processes are coordinated. BCDH kinase regulates BCDH by phosphorylation, thereby inactivating it when synthesis is required.

Pyruvate dehydrogenase kinase inhibits the pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. It is also involved in telomere maintenance.

This entry is associated with IPR003594 which is found towards the C terminus.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry BCDHK_Adom3