SMART: Pfam domain BH3

The domain within your query sequence starts at position 35 and ends at position 59; the E-value for the BH3 domain shown below is 5.6e-22.

DGGTMENLSRRLKVTGDLFDIMSGQ

BH3

PFAM accession number:	PF15285
Interpro abstract (IPR029318):	Beclin 1 is a tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [ (PUBMED:21311563) ]. The BH3 domain of Beclin 1 is bound to, and inhibited by Bcl-2 or Bcl-XL [ (PUBMED:17337444) ]. This interaction enables Bcl-2 to function not only as an antiapoptotic protein, but also as an antiautophagy protein [ (PUBMED:19641499) ].

PFAM accession number:

PF15285

Interpro abstract (IPR029318):

Beclin 1 is a tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [ (PUBMED:21311563) ]. The BH3 domain of Beclin 1 is bound to, and inhibited by Bcl-2 or Bcl-XL [ (PUBMED:17337444) ]. This interaction enables Bcl-2 to function not only as an antiapoptotic protein, but also as an antiautophagy protein [ (PUBMED:19641499) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry BH3