The domain within your query sequence starts at position 19 and ends at position 49; the E-value for the BaffR-Tall_bind domain shown below is 5.4e-26.



PFAM accession number:PF09256
Interpro abstract (IPR015336):

Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [ (PUBMED:8095800) (PUBMED:1377364) (PUBMED:15335677) ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [ (PUBMED:2989794) (PUBMED:3349526) ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine [ (PUBMED:2268312) ]. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers [ (PUBMED:2777790) ]. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [ (PUBMED:2777790) ].

There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.

The domain represented by this entry is predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R and is required for binding to tumour necrosis factor ligand TALL-1 [ (PUBMED:12721620) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry BaffR-Tall_bind