SMART: Pfam domain CENP-F_C_Rb

The domain within your query sequence starts at position 23 and ends at position 50; the E-value for the CENP-F_C_Rb_bdg domain shown below is 1.6e-17.

ASGFADIPTGKTSPYILRRTTMATRTSP

CENP-F_C_Rb_bdg

PFAM accession number:	PF10490
Interpro abstract (IPR018302):	This entry represents the Rb protein-binding domain from the centromere protein Cenp-F. Cenp-F is a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, that is involved in chromosome segregation during mitosis and is essential for the full functioning of the mitotic checkpoint pathway [ (PUBMED:7542657) (PUBMED:14555653) ]. Cenp-F interacts with retinoblastoma protein (RB), CENP-E and BUBR1. This domain is at the very C terminus of the C-terminal coiled-coil region, and binds to the Rb family of tumour suppressors [ (PUBMED:17498689) ].

PFAM accession number:

PF10490

Interpro abstract (IPR018302):

This entry represents the Rb protein-binding domain from the centromere protein Cenp-F. Cenp-F is a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, that is involved in chromosome segregation during mitosis and is essential for the full functioning of the mitotic checkpoint pathway [ (PUBMED:7542657) (PUBMED:14555653) ]. Cenp-F interacts with retinoblastoma protein (RB), CENP-E and BUBR1. This domain is at the very C terminus of the C-terminal coiled-coil region, and binds to the Rb family of tumour suppressors [ (PUBMED:17498689) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CENP-F_C_Rb_bdg