The domain within your query sequence starts at position 1714 and ends at position 1886; the E-value for the CHDCT2 domain shown below is 2.8e-98.
KTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLA RRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGN KPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRL
CHDCT2 |
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PFAM accession number: | PF08074 |
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Interpro abstract (IPR012957): | This entry represents the C-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [ (PUBMED:23340908) ]. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor [ (PUBMED:24419087) ]. There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues [ (PUBMED:23954449) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry CHDCT2