The domain within your query sequence starts at position 112 and ends at position 191; the E-value for the CSTF2_hinge domain shown below is 5.4e-32.



PFAM accession number:PF14327
Interpro abstract (IPR025742):

The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localisation. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex [ (PUBMED:19887456) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CSTF2_hinge