SMART: Pfam domain CTC1

The domain within your query sequence starts at position 60 and ends at position 1195; the E-value for the CTC1 domain shown below is < 1e-12.

TLPFSYSFVSVQSLKTHQRLPCCSHLSWSQSAYQAWTRGGRPGDGVLPREQLILLGTLVD
LLGDSEQECRSGSLYVRDNTGTLDCELIDLDLSWLGHLFLFPSWSYLPSAKRNSLGEGHL
ELWGTPVPVFPLTVSPGPLIPIPVLYPEKASHLLRYRKKSSIKEINLAGKLVHLSALIIT
QNKRYFIMTLGELAQAGSQVSIIVQIPAQMVWHRVLRPGRAYVLTKLQVTKTRIHLSCIW
TTIPSSTLKPLRPGYVQELELDLEFSKADLKPPPQPTSSKDSRGQEGLVRASKVLHYLGT
VTAVLHESAGLYILDGQLILCLAYQKIHGLRRVIRPGVCLELRDVHLLQAVGGATTKPVL
ALCLHGTVRLQGFSCLKPLTLPSSKVYGASLYEQLVWKCQLGLPLYLWAAKTLEDLIYKL
CPHVLRCHQFLKQPSPGKPSLGLQLLAPSWDVLIPPGSPMRHAYSEILEEPHNCPLQKYT
PLQTPYSFPTMLALAEEGQHRAWATFDPKAMLPLPEASHLTSCQLNRHLAWSWVCLPSCV
FQPAQVLLGVLVASSRKGCLELRDLRGSLPCIPLTESSQPLIDPNLVGCLVRVEKFQLVV
EREVRSSFPSWEEMGMARFIQKKQARVYVQFYLADALILPVPRPTFGSEPSQTASSCPEG
PHLGQSRLFLLSHKEALMKRNFCLLPGDSSQPAKPTLSFHVSGTWLCGTQRKEGSGWSPP
ESLAVESKDQKVFLIFLGSSVRWFPFLYPNQVYRLVASGPSTPVFETEGSAGTSRRPLEL
ADCGSCLTVQEEWTLELGSSQDIPNVLEVPRTLPESSLAQLLGDNSPDSLVSFSAEILSR
ILCEPPLALRRMKPGNAGAIKTGVKLTVALEMDDCEYPPHLDIYIEDPQLPPQIGLLPGA
RVHFSQLEKRISRSNIVYCCFRSSTSVQVLSFPPETKASAPLPHIYLAELLQGDRPPFQA
TTSCHIVYVLSLQILWVCAHCTSICPQGKCSRRDPSCPSQRAVSQANIRLLVEDGTAEAT
VICRNHLVARALGLSPSEWSSILEHARGPGRVALQFTGLGGQTESASKTHEPLTLLLRTL
CTSPFVLRPVKLSFALERRPTDISPREPSRLQQFQCGELPLLTRVNPRLRLVCLSL

CTC1

PFAM accession number:	PF15489
Interpro abstract (IPR029156):	In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation [ (PUBMED:19854130) ]. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 [ (PUBMED:20697207) ]. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex [ (PUBMED:19854130) ]. The mammalian CST complex may have both telomeric and non-telomeric function [ (PUBMED:19854130) ]. In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [ (PUBMED:20697207) ].
GO function:	single-stranded DNA binding (GO:0003697)

PFAM accession number:

PF15489

Interpro abstract (IPR029156):

In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation [ (PUBMED:19854130) ].

Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 [ (PUBMED:20697207) ]. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex [ (PUBMED:19854130) ]. The mammalian CST complex may have both telomeric and non-telomeric function [ (PUBMED:19854130) ].

In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [ (PUBMED:20697207) ].

GO function:

single-stranded DNA binding (GO:0003697)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CTC1