The domain within your query sequence starts at position 241 and ends at position 469; the E-value for the Casc1 domain shown below is 2.3e-11.

GFEIPRILATSNVALRLLHTRYDHITPLFPIAVTEQNQNPVGAEQVNVEESTEKAMTEEK
LFTEEKAANEDEQPKAEQERELNLVQEENKYEAIENTVLQRTSDSEGEDSQTTQLELEMK
LLSEAVLAAQLCLVENVVELPEASQAYKVDLCHFSTLGGVYHLDVLELPPQCKPVKGWVL
VEILQEGLQRFIYPPDTTEEPDPDVTFPPIEVTLEIHKSVIFFERPRVV

Casc1

 Casc1
PFAM accession number:PF12366
Interpro abstract (IPR022110):

This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Casc1