SMART: Pfam domain CbiA

The domain within your query sequence starts at position 70 and ends at position 241; the E-value for the CbiA domain shown below is 9.9e-17.

IVVASGKGGVGKSTTAVNLALALAANDSSKAVGLLDVDVYGPSIPKMMNLRGNPELSPNN
LMRPLLNYGIACMSMGFLVEETAPLVWRGLMVMSAIEKLLRQVDWGQLDYLVVDMPPGTG
DVQLSVSQNIPISGAVIVSTPQDIALMDAHKGAEMFRKVNVPVLGLVQNMSV

CbiA

PFAM accession number:	PF01656
Interpro abstract (IPR002586):	This domain is found in various cobyrinic acid a,c-diamide synthases. These include CbiA ( P29946 ) and CbiP ( Q05597 ) from S. typhimurium [ (PUBMED:8501034) ], and CobQ ( Q52686 ) from R. capsulatus [ (PUBMED:7635831) ]. These amidases catalyse amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria [ (PUBMED:8501034) ]. The domain is also found in dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [ (PUBMED:2149583) ].

PFAM accession number:

PF01656

Interpro abstract (IPR002586):

This domain is found in various cobyrinic acid a,c-diamide synthases. These include CbiA ( P29946 ) and CbiP ( Q05597 ) from S. typhimurium [ (PUBMED:8501034) ], and CobQ ( Q52686 ) from R. capsulatus [ (PUBMED:7635831) ]. These amidases catalyse amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria [ (PUBMED:8501034) ].

The domain is also found in dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [ (PUBMED:2149583) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CbiA