SMART: Pfam domain CoA_transf

The domain within your query sequence starts at position 39 and ends at position 406; the E-value for the CoA_transf_3 domain shown below is 3.4e-127.

LEGVRILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRSWGPPFVNTESTYFLSVN
RNKKSIAVNIKDPRGVRIVKELAAICDVFVENYVPGKLSEMGLGYEDIDKIAPHIIYCSI
TGYGQTGPMSHRAGYDAIASAMSGLMHITGPEDGDPVRPGVAMTDLATGLFAYGAIMAGL
LQRYRTGKGLFIDCNLLSSQVACLTQVAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGY
LVIGAGNNQQFAVVCKILNLPELIDDCKYRTNHLRVQNRKELVKILSARFAEEVTAKWLC
LFEGSGIPYGPINSLKDVFSEAQVLHNGLVMEMNHPTVGKISVPGPAVRYSKFKMSEAKP
PPLLGQHT

CoA_transf_3

PFAM accession number:	PF02515
Interpro abstract (IPR003673):	CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism: Family I consists of CoA-transferases for 3-oxoacids ( EC 2.8.3.5 EC 2.8.3.6 ), short-chain fatty acids ( EC 2.8.3.8 EC 2.8.3.9 ) and glutaconate ( EC 2.8.3.12 ). Most use succinyl-CoA or acetyl-CoA as CoA donors. Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase ( EC 2.8.3.10 EC 2.8.3.11 ). These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well. Family III consists of formyl-CoA:oxalate CoA-transferase [ (PUBMED:15213226) ], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [ (PUBMED:11418570) ], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [ (PUBMED:10849007) ], succinyl-CoA:mesaconate CoA-transferase [ (PUBMED:28932214) ] and butyrobetainyl-CoA:(R)-carnitine CoA-transferase [ (PUBMED:15823031) ]. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [ (PUBMED:11749953) ]. This entry represents family III CoA-transferases.
GO function:	CoA-transferase activity (GO:0008410)

PFAM accession number:

PF02515

Interpro abstract (IPR003673):

CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism:

Family I consists of CoA-transferases for 3-oxoacids ( EC 2.8.3.5 EC 2.8.3.6 ), short-chain fatty acids ( EC 2.8.3.8 EC 2.8.3.9 ) and glutaconate ( EC 2.8.3.12 ). Most use succinyl-CoA or acetyl-CoA as CoA donors.
Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase ( EC 2.8.3.10 EC 2.8.3.11 ). These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well.
Family III consists of formyl-CoA:oxalate CoA-transferase [ (PUBMED:15213226) ], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [ (PUBMED:11418570) ], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [ (PUBMED:10849007) ], succinyl-CoA:mesaconate CoA-transferase [ (PUBMED:28932214) ] and butyrobetainyl-CoA:(R)-carnitine CoA-transferase [ (PUBMED:15823031) ]. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [ (PUBMED:11749953) ].

This entry represents family III CoA-transferases.

GO function:

CoA-transferase activity (GO:0008410)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry CoA_transf_3