The domain within your query sequence starts at position 120 and ends at position 162; the E-value for the DUF4554 domain shown below is 1.6e-17.
MTDCLVIKHFLRKIIIVHHKLKFSFSVAVNGTLSAETFGSGRE
DUF4554 |
---|
PFAM accession number: | PF15091 |
---|---|
Interpro abstract (IPR028040): | This family of animal proteins is known as TOPOVIB-like as it shares strong structural similarity to the TopoVI DNA topoisomerase subunit B. TOPOVIB-like interacts and forms a complex with SPO11 and is required for meiotic DNA double-strand break formation [ (PUBMED:26917764) ]. TOPOVIB-like may be involved in the regulation of DNA cleavage. |
GO process: | meiotic DNA double-strand break formation (GO:0042138) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry DUF4554