SMART: Pfam domain Dapper

The domain within your query sequence starts at position 295 and ends at position 610; the E-value for the Dapper domain shown below is 9.6e-41.

GARPAREPSTERAWAAAWEAEVPPEPAPPAAASPPSSPAEGRLVKAQYIPGAPAASRGLP
GRAARRRAPPLTRGRSVEQSPPRERPRAAGRRGRLAEPSGRRGSPRARKAARSQSETSLL
GRAHAAPPPKYPTAERDEPRPPRPRRGPAPTPTVQACRRWRSTAEIDAPDGRRPRARVPA
PRGPAPSPSAPPRRLLYGCAGSDSECSAVGRPVPLGRRMPSGCAPGGYGESESSASEGES
PAFSSASSDSDGSGGLVWPQQLVAAAGASPSGPGGAAGGGTPAGPAKVFVKIKASHALKK
KILRFRSGSLKVMTTV

Dapper

PFAM accession number:	PF15268
Interpro abstract (IPR024843):	Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 [ (PUBMED:15539487) ]. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [ (PUBMED:16881060) ].

PFAM accession number:

PF15268

Interpro abstract (IPR024843):

Dact (dapper) proteins were identified through binding to dishevelled, a cytoplasmic protein central to Wnt signaling. The different dact proteins seem to have distinct signaling and developmental roles. In Zebrafish, dact1 but not dact2 is required to enhance Wnt/beta-catenin activity, while functional interaction with Wnt/Ca2+-PCP signaling has been described for dact2, but not dact1 [ (PUBMED:15539487) ]. Data from other vertebrates seems to be consistent with a distinct signaling and developmental role for dact1, dact2 and dact3 [ (PUBMED:16881060) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Dapper