The domain within your query sequence starts at position 54 and ends at position 375; the E-value for the Diphthamide_syn domain shown below is 2.8e-64.

FPDQLLGDAGAVAARLEEVTGAKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSP
PASQLPITFVLGQRPVALELCAKAFEAQNPDPTAPVVLLSEPACAHALEPLAMLLLPKYQ
DLLISRPALPLPVGSPSSQPESLERFGRCFPLNPGRRLEEYGAFYVGASQASSDSSLDPD
LSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLIERARDARVVGLLAGTLGV
ARHREALAHLRKLTEAAGKRSYVLAVGKPTPAKLANFPEMDVFVLLACPLGALAPQPSGG
FFRPVLTPCELEAACNPAWPPP

Diphthamide_syn

Diphthamide_syn
PFAM accession number:PF01866
Interpro abstract (IPR016435):

Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [ (PUBMED:15485916) ].

Members of this family include DPH1 and DPH2, which are involved in the first step of diphthamide synthesis [ (PUBMED:15485916) ]. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 [ (PUBMED:20559380) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Diphthamide_syn