The domain within your query sequence starts at position 89 and ends at position 245; the E-value for the Dishevelled domain shown below is 1.3e-63.



PFAM accession number:PF02377
Interpro abstract (IPR003351):

This domain is specific to the signalling protein dishevelled. Dishevelled (Dsh/Dvl) is a highly conserved protein family that plays an important role in mediating Wnt signaling. Wnt signal transduction pathways control a variety of developmental and homeostatic events. Dishevelled is involved in both the canonical and non-canonical (B-catenin-independent) pathways [ (PUBMED:20006983) ].

This domain is found adjacent to the PDZ domain ( IPR001478 ), often in conjunction with DEP ( IPR000591 ) and DIX ( IPR001158 ).

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Dishevelled