SMART: Pfam domain FOXO-TAD

The domain within your query sequence starts at position 497 and ends at position 538; the E-value for the FOXO-TAD domain shown below is 7.3e-24.

PDRFPADLDLDMFSGSLECDVESIILNDFMDSDEMDFNFDSA

FOXO-TAD

PFAM accession number:	PF16676
Interpro abstract (IPR032067):	TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the KIX-binding domain bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300 [ (PUBMED:22474372) ].

PFAM accession number:

PF16676

Interpro abstract (IPR032067):

TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the KIX-binding domain bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300 [ (PUBMED:22474372) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FOXO-TAD