The domain within your query sequence starts at position 1 and ends at position 228; the E-value for the F_actin_cap_B domain shown below is 4.7e-111.
MRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYR SPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVI LIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGS LTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIV
F_actin_cap_B |
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PFAM accession number: | PF01115 |
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Interpro abstract (IPR001698): | The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) and thereby restricts its growth. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins [ (PUBMED:2341404) ]. This entry represents the beta subunit (CAPZB), which is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [ (PUBMED:2179733) ]. In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration [ (PUBMED:16143599) ]. In humans CAPZB is part of the WASH complex that controls the fission of endosomes [ (PUBMED:19922875) ]. |
GO process: | barbed-end actin filament capping (GO:0051016) |
GO component: | F-actin capping protein complex (GO:0008290) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry F_actin_cap_B