The domain within your query sequence starts at position 104 and ends at position 265; the E-value for the Folliculin domain shown below is 1.5e-55.



PFAM accession number:PF11704
Interpro abstract (IPR037520):

This is the N-terminal domain of folliculin. This domain shares structural similarity with DENN domain of DENN1B (a Rab GEF), and has guanine nucleotide exchange factor (GEF) activity [ (PUBMED:22977732) ]. This domain can also be found in SMCR8, a component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy [ (PUBMED:20562859) (PUBMED:27193190) (PUBMED:27103069) (PUBMED:27559131) (PUBMED:27617292) (PUBMED:28195531) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Folliculin