The domain within your query sequence starts at position 5 and ends at position 129; the E-value for the GRIM-19 domain shown below is 9.6e-53.



PFAM accession number:PF06212
Interpro abstract (IPR009346):

This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity [ (PUBMED:12628925) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry GRIM-19