The domain within your query sequence starts at position 1 and ends at position 214; the E-value for the Glyco_transf_18 domain shown below is 3e-116.



PFAM accession number:PF15024
Interpro abstract (IPR026116):

The glycosyltransferase family 18 consists of alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferases. This enzyme catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

In humans, two homologues have been described, Gnt-V(A) and Gnt-VB (GnT-IX). Gnt-VB is predominantly expressed in brain and catalyses the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Gnt-VB could be responsible for the synthesis of a unique oligosaccharide structure in the brain. It plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway [ (PUBMED:14623122) (PUBMED:12941944) (PUBMED:14617637) (PUBMED:16857188) (PUBMED:16606368) ].

Caenorhabditis elegans has only one homologue [ (PUBMED:11937505) ].

GO process:protein N-linked glycosylation (GO:0006487)
GO function:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity (GO:0030144)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Glyco_transf_18