The domain within your query sequence starts at position 451 and ends at position 784; the E-value for the HAD domain shown below is 2.4e-16.

ICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTLELLVNAIAINSAYTTKILPP
EKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKM
PDESFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMACDGLRTICVA
YRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI
NTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTD
KHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALK

HAD

 HAD
PFAM accession number:

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HAD