SMART: Pfam domain MCM

The domain within your query sequence starts at position 36 and ends at position 588; the E-value for the MCM_bind domain shown below is 3.6e-210.

FKEKLKENNAPKWVPSLNEVPLHYLKPNSFVKFRCMIQDMFDPEFYMGIYETVNQNTKAR
VLHFGKYRDVAECGPQQELDLSSPRSTTSERQTFYCVPVPGESSWVKEAYVNANQARVSP
STSYTPSRHKRSYEDDEDMDLQPSKQKEQHPGSRQAGGLGGLHWCGEPKRLETEASSGQQ
LNTLNLSSPFDLNFPLPGEKGPACLVKVYEDWDCFKVNDVLELYGVLSVDPVLSVLNSEE
RDASALLDPMECTDMAEEQRVHSPPASLVPRIHVILAQKLQHINPLLPTCLNKEESRSCQ
FVSNFMSELSPVRAELLGFLTHALLGDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSG
CPQNSTFTEHLYRIIQHLVPASFRLQMTIENMNQLKLIPHKDYTANRLVSGLLQLPNNTS
LVIDETLLEQGQLDTPGVHNVTALSNLITWQKVDYDFSYHQMEFPCNINVLITSEGRSLL
PADCQIHLQPQLIPPNMEEYMNGLLSAVLPSVLNKFRIYLTLLRFLDYNLSDDITKIPVS
ERRSDNTLQRALA

MCM_bind

PFAM accession number:	PF09739
Interpro abstract (IPR019140):	This entry represents a family of proteins which are approximately 600 residues in length and contain alternating regions of conservation and low complexity. They are associated components of the mini-chromosome maintenance (MCM) complex that acts as a regulator of DNA replication. They bind to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilising interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion [ (PUBMED:21196493) (PUBMED:20090939) ].

PFAM accession number:

PF09739

Interpro abstract (IPR019140):

This entry represents a family of proteins which are approximately 600 residues in length and contain alternating regions of conservation and low complexity. They are associated components of the mini-chromosome maintenance (MCM) complex that acts as a regulator of DNA replication. They bind to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilising interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion [ (PUBMED:21196493) (PUBMED:20090939) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MCM_bind