The domain within your query sequence starts at position 87 and ends at position 435; the E-value for the MGAT2 domain shown below is 2.4e-158.
RSLVYQLNFDQMLRNVGNDGTWSPGELVLVVQVHNRPEYLRLLIDSLRKAQGIQEVLVIF SHDFWSAEINSLISRVDFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLKKNAALKLGCI NAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKVLQDYTGLILFLEEDHYLAPDFYHV FKKMWKLKQQECPGCDVLSLGTYTTIRSFYGIADKVDVKTWKSTEHNMGLALTRDAYQKL IECTDTFCTYDDYNWDWTLQYLTLACLPKIWKVLVPQAPRIFHAGDCGMHHKKTCRPSTQ SAQIESLLNSNKQYLFPETLVIGEKFPMAAISPPRKNGGWGDIRDHELC
MGAT2 |
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PFAM accession number: | PF05060 |
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Interpro abstract (IPR007754): | N-acetylglucosaminyltransferase II ( EC 2.4.1.143 ) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [ (PUBMED:7797505) ]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors [ (PUBMED:11596651) ]. |
GO process: | oligosaccharide biosynthetic process (GO:0009312) |
GO component: | integral component of membrane (GO:0016021), Golgi stack (GO:0005795) |
GO function: | alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity (GO:0008455) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry MGAT2